Extended Data Fig. 6: Bidirectional flow imaging experiment demonstrates that omissions are locked to outward then inward CSF flow. | Nature Neuroscience

Extended Data Fig. 6: Bidirectional flow imaging experiment demonstrates that omissions are locked to outward then inward CSF flow.

From: Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics

Extended Data Fig. 6: Bidirectional flow imaging experiment demonstrates that omissions are locked to outward then inward CSF flow.

(A) Positioning of acquisition protocol for the second experiment, designed to measure bidirectional flow. Acquisition volume enabled simultaneous measures of outward flow (measured in the top slice) and inward flow (measured in the bottom slice). (B) This bidirectional imaging experiment replicated the coupling between omissions and CSF flow. CSF flow moves outward at the omission, and moves inward at the recovery of attention. (n = 114 trials, 10 subjects). CSF outflow signal is inverted to match directionality (down is outward flow). CSF flow is averaged relative to isolated omissions during wakefulness. Black bars indicate significant (p < 0.05, paired t-test, Bonferroni corrected) changes from baseline ([-10 -5] s). Data are presented as mean values ± standard error. Shading is standard error across segments.

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