Extended Data Fig. 2: Pupil cross-correlation with the CSF signals during drowsiness. | Nature Neuroscience

Extended Data Fig. 2: Pupil cross-correlation with the CSF signals during drowsiness.

From: Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics

Extended Data Fig. 2

Cross-correlation was computed between pupil and CSF during two different conditions: 1) 60 s segments in rested wakefulness, 2) 60 s segments in sleep deprivation. All segments had at least one response time that was longer than 500 ms. Maximal cross-correlation r was observed during sleep-deprived condition with at least one CSF peak. A negative lag indicates pupil activity leads CSF activity. Segment length was 60 s. Black bars indicate significant (rested segments: n = 571; sleep deprived segments: n = 412; p < 0.05, paired t-test, Bonferroni corrected.) Data are presented as mean values ± standard error. Shading is standard error across segments.

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