Extended Data Fig. 4: Additional cortical gray matter BOLD, CSF and systemic physiology measures are coupled to omission trials. | Nature Neuroscience

Extended Data Fig. 4: Additional cortical gray matter BOLD, CSF and systemic physiology measures are coupled to omission trials.

From: Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics

Extended Data Fig. 4

(A) CSF flow at both well-rested and sleep deprived session showed a biphasic change locked to the omission trial onset. The mean CSF signal in the sleep deprived session was 3.3 percentage points higher than in the well-rested session. (B) Cortical BOLD signals in both well-rested (n = 87 segments) and sleep-deprived (n = 277 segments) sessions showed a similar biphasic pattern as the ventricular CSF, although with a dip in signal amplitude seconds before the omission trial onset. (C) Respiratory volume per time showed biphasic changes locked to omission trials onset. (D) Peripheral vascular volume also showed biphasic changes locked to omission trials onset. Black bars indicate significant difference from baseline (paired t-test, Bonferroni corrected, p < 0.05); same segments as in Fig. 3. Data are presented as mean values ± standard error across segments.

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