Extended Data Fig. 10: [11C]PBR28 TSPO PET signature in AD.
From: Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease
![Extended Data Fig. 10: [11C]PBR28 TSPO PET signature in AD.](http://media.springernature.com/full/springer-static/esm/art%3A10.1038%2Fs41593-025-02103-0/MediaObjects/41593_2025_2103_Fig12_ESM.jpg?as=webp)
(a) Region-wise TSPO PET SUVR mean maps in CU Aβ- individuals (top) and AD Aβ+ dementia patients (middle), along with the region-wise differences of TSPO PET SUVR mean maps (bottom), computed as mean SUVR values in AD Aβ+ minus CU Aβ-. Of note, the bottom panel displays only regions with significantly higher TSPO PET signal in AD Aβ+ compared to CU Aβ- (T-value > 2). (b) Bars display the mean and SD of TSPO PET SUVR across groups in the posterior cingulate, which is the region showing the greatest difference between AD Aβ+ and CU Aβ-. (c) Bars display the mean and SD of TSPO PET SUVR across groups in a composite brain region comprising the areas that show higher TSPO PET SUVR values (T-value > 2) in AD Aβ+ compared to CU Aβ-. This T-derived composite brain region was estimated from the following brain regions: caudal anterior cingulate, entorhinal, fusiform, inferior temporal, isthmus cingulate, lateral orbitofrontal, lingual, medial orbitofrontal, middle temporal, paracentral, parahippocampal, pars opercularis, pars orbitalis, pars triangularis, pericalcarine, posterior cingulate, precuneus, rostral middle frontal, superior frontal. (d) Bars display the mean and SD of TSPO PET SUVR across groups in a composite brain region comprising the areas within the top decile for absolute TSPO PET SUVR differences between AD Aβ+ and CU Aβ-. This difference-derived composite brain region was estimated from the following brain regions: paracentral, pars triangularis, posterior cingulate, and precuneus. Two-sided P-values correspond to group comparison (AD Aβ+ vs. CU Aβ-) from regression analyses accounting for age and sex. Exact P-values are (b) 1.99 × 10−5, (c) 6.86 × 10−5, (d) 4.51 × 10−5. n = 62; 49 CU Aβ- (11 males, mean [SD] age of 71.5 [5.7] years) and 13 AD Aβ + (6 males, mean [SD] age of 68.9 [10.3] years). Abbreviations: AD = Alzheimer’s disease; Aβ = amyloid-β; CU = cognitively unimpaired; PET = positron emission tomography; SD = standard deviation; SUVR = standardized uptake value ratio; TSPO = translocator protein.
