Extended Data Fig. 5: Analysis testing the association of CSF sTREM2 and Aβ PET with plasma GFAP stratifying individuals by study cohort.
From: Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease
Scatter plots displaying the association between global Aβ PET burden and plasma GFAP levels according to MAsTREM2 status in the (a) WRAP (MA+sTREM2: exact P = 1.45 × 10−4) and (b) TRIAD (MA+sTREM2: exact P = 7.43 × 10−7) cohorts. Error bands represent the 95% CI of regression lines. β-estimates and two-sided P-values were computed from linear regression models using standardized fluid biomarker levels and Aβ PET in centiloids, with adjustments for age, sex, and cognitive status. The interaction models also accounted for the main effects of the interaction terms. Abbreviations: Aβ = amyloid-β; CI = confidence interval; CSF = cerebrospinal fluid; GFAP = glial fibrillary acidic protein; MA = microglial activation; PET = positron emission tomography; sTREM2 = soluble triggering receptor expressed on myeloid cells 2; TRIAD = Translational Biomarkers in Aging and Dementia; WRAP = Wisconsin Registry for Alzheimer’s Prevention.
