Extended Data Fig. 2: Comparisons of normative references by different FreeSurfer versions, different populations, and extended brain atlases.
From: Charting brain morphology in international healthy and neurological populations
a, The consistency analysis of the raw global and regional brain structural measures derived from FreeSurfer 6 and 7. b, The CH normative references fitted by the segmentation outputs of FreeSurfer 6 and 7, with the ENA and ENA-calibrated normative references as comparisons. The units are \(\times {10}^{4}{{mm}}^{3}\) for volume measures, \(\times {10}^{4}{{mm}}^{2}\) for area measure, and \({mm}\) for thickness measure. c, consistency analysis of the normative references (median curves) between different FreeSurfer version and populations. d, The milestones (peak ages) of normative references constructed by outputs of FreeSurfer 6. e, The peak age differences of regional structural normative references. Only the available peak ages in both CH and ENA normative references were displayed. f, The peak ages of the normative references based on the extended brain parcellation atlas, including HCP-MMP1.0 parcellation (Human Connectome Project Multi-Modal Parcellation version 1.0), DU15NET, and Brainnetome Atlases. Note: CH, Chinese; CCC, Concordance Correlation Coefficient; GMV, gray matter volume, sGMV, subcortical gray matter volume; WMV, white matter volume; CSF, cerebrospinal fluid; v6, FreeSurfer version 6; v7, FreeSurfer version 7; yr, year.
