Extended Data Fig. 9: AEA facilitates the LTP induced by STDP protocol. | Nature Neuroscience

Extended Data Fig. 9: AEA facilitates the LTP induced by STDP protocol.

From: Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus

Extended Data Fig. 9: AEA facilitates the LTP induced by STDP protocol.

(a) Time course of the EPSC amplitude before and after LTP induced by STDP protocol (Δt = 20 ms) in control condition (n = 5, p < 0.001; black circles, control), and in the presence of AEA (3 µM, n = 5, p < 0.05; red circles, AEA + t-LTP). Scale bars 10 mV, 50 ms. (b) Relative EPSC amplitude in control condition (n = 5; black bar, control) and in the presence of AEA (3 µM, n = 5; red circles, AEA + t-LTP) after STDP protocol (STDP Control vs. STDP AEA, n = 5, p < 0.05). (c) Time course of the EPSC amplitude before and after STDP protocol (Δt = 50 ms) in control condition (n = 5, p = 0.9; black circles, control), and in the presence of URB-597 (1 µM, n = 5, p < 0.05; red circles, URB-597). Scale bars 10 mV, 50 ms. Adult animals ( ≥ 6 weeks; males and females) were used; *p < 0.05, **p < 0.01, ***p < 0.001; Student’s unpaired t-test. Data are mean ± s.e.m.

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