Extended Data Fig. 3: Intrinsic properties of pyramidal neurons classified according to IDH status. | Nature Neuroscience

Extended Data Fig. 3: Intrinsic properties of pyramidal neurons classified according to IDH status.

From: Increased neural excitability and glioma synaptic activity drives glioma proliferation in human cortex

Extended Data Fig. 3

Biophysical properties of neurons recorded from tissue clinically determined as IDH wildtype (WT) or IDH-mutant (mutant). (a-f) Comparison between IDH-WT (light blue; n = 69 cells) and IDH-mutant (light green; n = 85 cells) for action potential (AP) (a) Amplitude (p = 0.0003), (b) Threshold (p = 0.005), (c) Max rate of rise (p = 0.01), (d) Rheobase (p = 0.178), (e) Half-Width (p = 0.328), (f) Rise-time (p = 0.924), (g) Adaptation ratio (p = 0.633), (h) Total number of APs (up to 510 pA), (i) Resting membrane potential (RMP, p = 0.458). Mean values are represented as bold lines. All data were analyzed using a linear mixed-effect model. ns, p > 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

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