Extended Data Fig. 1: Differences in axon-myelin properties between DC and VC.
From: TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
a-c TEM analysis showing the density of myelinated axons (b) and the average axon size (c) in the DC and VC of mice aged 2-3 months, 12 months, and 16-18 months; scale bar=20μm; n = 10, 6, and 9 mice for the 2-3 mo, 12 mo, 16-18 mo age groups, respectively. d-f Immunostaining of MBP (red) and dMBP (green) in the DC and VC across age groups, with quantification of dMBP+ area in (e) and an inset of the DC of 18-23 month mice in (f); scale bar=50μm; n = 6 mice per group. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001; two-way ANOVA with Tukey’s post-hoc test.
