Extended Data Fig. 5: Neuroanatomical phenotypes associated with Eml1, Dynlrb2, Sgms1, and Mta3 when inactivated in mice.

Neuroanatomical data are shown using the parasagittal plane at Lateral 0.60 mm with numbered measurements (total of 40) and coronal planes at Bregma +0.98 mm and Bregma −1.34 mm with numbered measurements (total of 39) expressed as a percentage of wild-type brain corresponding structures using histograms. Positive and negative values correspond to increased and decreased measurements relative to matched control mice, respectively. The color code indicates the significance threshold: white when not significant, and gray when not computable. a, Mouse Eml1−/− neuroanatomical data plotted as bar plots (top left) and representative sagittal brain scan images and double-stained (bottom) using Nissl-Luxol showing the heterotopia (region delineated in white) and the fibers that have rerouted (white arrows) at Lateral 0.60 mm. Scale bars = 0.1 cm. b, Mouse Dynlrb2+/− neuroanatomical data plotted as bar plots (top left) and representative coronal brain scan images (bottom) double-stained using Nissl-Luxol showing the enlarged size of the lateral ventricles indicated using asterisks at Bregma −1.34 mm. Scale bars = 0.2 cm. c, Mouse Sgms1−/− neuroanatomical data plotted as bar plots (top left) and representative coronal brain scan images (bottom) double-stained using Nissl-Luxol showing a zoomed-in region where the lateral ventricles are abnormally smaller in size at Bregma −1.34 mm. Scale bars = 0.1 cm. d, Mouse Mta3−/− neuroanatomical data plotted as bar plots (left) and coronal brain section defined according to the Allen Mouse Brain Atlas at Bregma −1.34 mm (right). Scale bars = 0.1 cm. e, List of neuroanatomical parameters and corresponding numbers on the coronal and sagittal planes (a full description is provided in Supplementary Table 6, and overlays are available in Extended Data Fig. 3).