Extended Data Fig. 9: HOX-associated chromatin states in adult OLGs mirror regulatory programs in HGG. | Nature Neuroscience

Extended Data Fig. 9: HOX-associated chromatin states in adult OLGs mirror regulatory programs in HGG.

From: Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

Extended Data Fig. 9: HOX-associated chromatin states in adult OLGs mirror regulatory programs in HGG.

a, Schematic of the adult human brain showing the location of pontine and thalamic gliomas along the A-P axis. Schematic in a created in BioRender. Castelo-branco, G. https://BioRender.com/orfbpyi (2025). b, snATAC-seq and nanoCUT&Tag normalized promoter accessibility (ATAC), H3K27ac and H3K27me3 signal in spinal cord OLGs (top) and cortical OLGs (bottom) at different developmental genes associated with brain and spinal cord patterning. c, Genome browser tracks showing nanoCUT&Tag H3K27ac and H3K27me3 pseudobulk signal coverage at the HOXA cluster in spinal cord (SC) derived adult human OLG (hOLG) and PFA-EP tumors, H3.3K27M pontine tumors, and H3.3K27M thalamic tumors11. d, Same as c, but at the HOXD locus.

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