Extended Data Fig. 1: QC and preprocessing of the snATAC-seq dataset.

a, Schematic showing downstream data analysis workflow. b, Density scatter QC plots for all 48 samples in the snATAC-seq dataset. Number of unique fragments (log scale) on x axis and TSS enrichment score on y axis. c, Violin plots showing number of unique fragments (log) from each donor (top) and each sample (bottom). Data in each violin plot composed of all cells within that donor (top) or sample (bottom). Black box within each violin plot represents the interquartile range (IQR), white dot is the median, and whiskers extend to 1.5× IQR.