Fig. 5: Pressure applied to the abdomen of anesthetized mice resulted in rostro-lateral brain motion.
From: Brain motion is driven by mechanical coupling with the abdomen
a, A mouse was lightly anesthetized with isoflurane and wrapped with an inflatable belt around the abdomen. b, Displacement of the brain relative to the skull (green) for a single abdominal compression trial (data in c). The brain was displaced rostrally and slightly laterally. c, Displacements of the brain (green) and skull (magenta) during abdominal compressions delivered to the anesthetized mouse (below). d, Brain displacement during abdominal compression trials across the brain (109 trials spread between 36 locations in six mice, averaged by location). The motion trend is in the rostro-lateral direction, as seen with brain motion during locomotion. Generated using brainrender60. e, Abdominal compression-triggered average of brain motion for each trial in the medial-lateral (green) and rostral-caudal (blue) direction. Black line: mean; shading: 90% confidence interval; N = 109 abdominal compression trials. The brain begins moving immediately upon abdominal pressure application and continues to displace as the compression continues. Upon pressure release, the brain returns quickly to baseline. f, Abdominal compression-triggered skull motion averages for each trial in the medial-lateral (green) and rostral-caudal (blue) direction. Black line: mean; shading, 90% confidence interval; N = 109 abdominal compression trials.
