Extended Data Fig. 3: 3D reconstructions of CA hexamer from five helical symmetries. | Nature Structural & Molecular Biology

Extended Data Fig. 3: 3D reconstructions of CA hexamer from five helical symmetries.

From: Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

Extended Data Fig. 3

a, Electron density maps of CA tubes in the absence and presence of CypA and with different helical symmetries, as indicated. b, Fourier-shell-correlation (FSC) plots of CA hexamer density maps reconstructed from five helical symmetries. The highest resolution at FSC=0.143 is 3.6 Å from (-13, 8) symmetry. c, The FSC plot between the refined CA hexamer model and the 3.6 Å cryoEM density map from (-13, 8) symmetry. d, Representative density map from (-13, 8) symmetry overlapped with the refined atomic model, shown are the helices between adjacent CA monomers in different color. The map was contoured at 2𝜎.

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