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CELL SIGNALING

Diverse activation mechanisms of PI3Ks

Nature Structural & Molecular Biology volume 29, pages 185–187 (2022)Cite this article

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The class II phosphatidylinositol 3-kinases (PI3Ks) serve important roles in diverse cellular processes. The lab of Volker Haucke has now determined high-resolution structures of mouse PI3KC2α in both active and inactive conformations, elucidating the autoregulatory mechanism of class II PI3K activation.

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Fig. 1: The PI3K family and the structural architecture of PI3KC2α.
Fig. 2: Activation of PI3KC2α.

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Authors and Affiliations

  1. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China

    Pujuan Deng & Jun-Jie Gogo Liu

  2. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

    Pujuan Deng & Jun-Jie Gogo Liu

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  1. Pujuan Deng
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  2. Jun-Jie Gogo Liu
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Correspondence to Jun-Jie Gogo Liu.

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Deng, P., Liu, JJ.G. Diverse activation mechanisms of PI3Ks. Nat Struct Mol Biol 29, 185–187 (2022). https://doi.org/10.1038/s41594-022-00744-4

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