Endosomes articles from across Nature Portfolio

Although deregulation of ferroptosis is of interest in cancer therapy, the molecular mechanisms that govern its regulation remain unclear. A study now identifies TMEM87a as a mediator of ferroptosis resistance, establishing a mechanistic link to Golgi pH homeostasis, and explores its relevance to immune checkpoint therapy.

The ESCRT-protein HRS undergoes two-dimensional phase separation on endosomal membranes to form gel-like condensates that recruit clathrin into multilayered, flat coats. Cholesterol enhances this process and drives stable cargo-sorting microdomains

Germ granule components maintain protein levels of endolysosomal components via small RNA-mediated regulation during the oocyte-to-embryo transition, thereby ensuring spatiotemporal endosomal activation (endosomal switching) for proper embryogenesis.

This study identifies the retromer–SNX27 complex as a key regulator of stress-induced Golgi-bypass trafficking, enabling membrane proteins including CFTR and the SARS-CoV-2 spike protein to reach the cell surface.

Du, Miao et al identify that the spatiotemporal recruitment and activation of Rab5 during early endosome formation are collectively determined by Rabex5/hRME6 recruitment and PI(4,5)P2 depletion during uncoated endocytic carrier formation.

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.

Although deregulation of ferroptosis is of interest in cancer therapy, the molecular mechanisms that govern its regulation remain unclear. A study now identifies TMEM87a as a mediator of ferroptosis resistance, establishing a mechanistic link to Golgi pH homeostasis, and explores its relevance to immune checkpoint therapy.

Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. Cell biologists now find another ageing-associated function for Rubicon — the release of exosomes containing microRNAs that control senescence and longevity.

The commander complex was recently shown through interactomic screens to be a ubiquitous and conserved protein complex with fundamental biological roles. Two recent reports together revealed the structure of the complete commander assembly and explored its functional implications.

Despite a growing understanding of the immunostimulatory properties of mitochondrial DNA (mtDNA), little is known about how and why mtDNA escapes its mitochondrial confines. A study now describes an endosomal trafficking pathway that facilitates mtDNA egress and provides an additional mechanism of mtDNA release in vitro.