Extended Data Fig. 7: Structural comparison of GATOR1 in GAP mode and KICSTOR-bound conformations.
From: Architecture of the human KICSTOR and GATOR1–KICSTOR complexes
a, Structural alignment of GATOR1 in this study with the reported GAP-mode conformation (PDB 7T3B). Depdc5, Nprl2, and Nprl3 are colored in forest green/light-sky blue, dark salmon/yellow, and thistle/yellow-green, respectively, and presented in two different orientations. b, Close-up view of the Nprl3 longin-TINI domains (PDB 7T3B). c, Close-up view of the Nprl3 longin-TINI domains bound to SZT2NTD. d, Cryo-EM densities fitted to the Nprl3TINI model. e, The map covering the interface between Nprl3-SZT2. f, Structural alignment of Nprl2 with its GAP-mode conformation (PDB 7T3B). RMSD values for the superimposed structures are shown in Supplementary Table 2.
