Extended Data Fig. 2: Multiple sequence alignment.
From: Structural visualization of the molecular evolution of CRISPR–Cas9
Multiple sequence alignment of HfmIscB, TbaIscB, YnpsCas9, and NbaCas9. HfmIscB, IscB from the human fecal metagenome (Ga0169696_100022); TbaIscB, IscB from Tissierellia bacterium (JAAZKS010000250.1); YnpsCas9, Cas9 from the sediment metagenome in Yellowstone National Park (Ga0315277_10040887); NbaCas9, Cas9 from Nitrospirae bacterium (MHDT01000042.1). The figure was prepared using Clustal Omega (https://www.ebi.ac.uk/jdispatcher/msa/clustalo) and ESPript 3.0 (https://espript.ibcp.fr/ESPript/ESPript).
