Extended Data Fig. 5: AERP. | Nature Protocols

Extended Data Fig. 5: AERP.

From: In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability

Extended Data Fig. 5: AERP.The alternative text for this image may have been generated using AI.

(Upper) Stimulation protocol parameters, surface ECG lead II and intracardiac leads HRAp, RVd and RVp are displayed during atrial stimulation. At a critical S2S3 interval, no atrial response is elicited because the atrial tissue is still refractory. AERP is determined as the first (longest) S2S3 interval with loss of atrial depolarization. (Lower) Representative refractory curve and recovery curve of the atrial myocardium. The curves are determined by premature stimulation using the protocol described in the upper panel. Representative recordings and graphical analysis are obtained from a 4-month-old male mouse.

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