Fig. 2
From: Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution
Summary of demographics and clinical data of the PsychAD cohort. (a) Overlap of the PsychAD cohort with MSSM AMP-AD, CommonMind and RADC cohorts. (b) Correlations among AD-related phenotypes. This analysis includes donors with either sole AD diagnosis (without comorbidities) or control samples (free of any diagnosis). For the “cognitive impairment” phenotype, untransformed CDR values are used for MSSM donors. RADC donors are numerically scaled as follows: Mild Cognitive Impairment (MCI) = 0.75, clinical dementia = 3. (c) Distribution of the number of diagnoses per donor. Note that “Dementia” and “MCI” are not counted as separate diagnoses if the donor already has a neurodegenerative or neurological disease. Also, NPS are excluded from this comparison. (d) Analysis of the counts and intersections among the top 10 most frequently represented diagnoses plus controls, with a minimum intersection size for plotting set to 10. FTD: Frontotemporal dementia; ASCVD: Atherosclerotic cardiovascular disease; PD: Parkinson’s disease; BD: Bipolar disorder; Diabetes: Diabetes mellitus Type 1/2/unspecified; Vascular: Vascular dementia; DLBD: Diffuse Lewy body disease; SCZ: Schizophrenia. (e–h) Exploration of demographic and clinical variables within subcohorts of samples from the three brain tissue sources, encompassing sex (e), genetically inferred ancestry (f), age (g), and disease status (h). NPS are not included in the disease count in (h). (i) Dendrogram of NPS based on their co-occurrence with three highlighted clusters.
