Table 1 Summary of all diagnoses recognized within the PsychAD cohort.
From: Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution
Disease | Categorya | Sample size | Age of death (mean) | |||||
|---|---|---|---|---|---|---|---|---|
Total | MSSM | HBCC | RADC | MSSM | HBCC | RADC | ||
Dementiab | NDD | 752 | 666 | 0 | 86 | 82.7 | 85.1 | |
Alzheimer’s diseasec | NDD | 519 | 447 | 0 | 72 | 84.3 | 85.8 | |
Schizophrenia | SMI | 177 | 127 | 50 | 0 | 72.1 | 52.1 | |
Mild cognitive impairementd | NDD | 125 | 103 | 0 | 22 | 77.4 | 83.4 | |
Diffuse Lewy body disease | NDD | 112 | 107 | 0 | 5 | 82.1 | 80.7 | |
Vascular dementia | NDD | 85 | 65 | 0 | 20 | 82.7 | 83.9 | |
Bipolar disorder type I | SMI | 55 | 0 | 55 | 0 | 43.7 | ||
Tauopathye | NDD | 45 | 33 | 0 | 12 | 87.6 | 84.1 | |
Diabetes mellitus unspecified | MD | 42 | 0 | 1 | 41 | 75.0 | 87.9 | |
Atherosclerotic cardiovascular disease | MD | 40 | 0 | 40 | 0 | 48.1 | ||
Parkinson’s disease | NDD | 40 | 25 | 0 | 15 | 81.8 | 80.3 | |
Type 1 diabetes | MD | 16 | 0 | 16 | 0 | 55.6 | ||
Frontotemporal dementia | NDD | 16 | 15 | 0 | 1 | 78.1 | 67.4 | |
Neuroleptic-induced tardive dyskinesia | SMI | 14 | 0 | 14 | 0 | 53.0 | ||
Head injury | NDD | 12 | 6 | 0 | 6 | 68.3 | 85.2 | |
Seizures | NDD | 12 | 0 | 12 | 0 | 48.2 | ||
Type 2 diabetes | MD | 11 | 0 | 11 | 0 | 53.7 | ||
Encephalitis, uncertain Parkinson’s disase | NDD | 8 | 8 | 0 | 0 | 79.1 | ||
Brain tumor | NDD | 8 | 7 | 1 | 0 | 75.3 | 45.0 | |
Cerebral atrophy | NDD | 7 | 7 | 0 | 0 | 71.0 | ||
Bipolar disorder type II | SMI | 7 | 0 | 7 | 0 | 43.7 | ||
Amyotrophic lateral sclerosis | NDD | 6 | 5 | 0 | 1 | 79.0 | 53.8 | |
BD NOS (not otherwise specified) | SMI | 6 | 0 | 6 | 0 | 35.7 | ||
Obsessive-compulsive disorder | SMI | 6 | 0 | 6 | 0 | 47.5 | ||
Progressive supranuclear palsy | NDD | 5 | 5 | 0 | 0 | 80.6 | ||
Leucotomy/Lobotomy | NDD | 4 | 4 | 0 | 0 | 79.8 | ||
Anorexia nervosa | SMI | 4 | 0 | 4 | 0 | 42.8 | ||
Schizoaffective bipolar disorder | SMI | 4 | 0 | 4 | 0 | 45.8 | ||
Argyrophilic grain disease | NDD | 3 | 3 | 0 | 0 | 83.0 | ||
Multiple sclerosis | NDD | 3 | 3 | 0 | 0 | 41.7 | ||
Normal pressure hydrocephalus | NDD | 3 | 3 | 0 | 0 | 83.0 | ||
Bulimia nervosa | SMI | 3 | 0 | 3 | 0 | 47.0 | ||
Major depressive disorder | SMI | 3 | 2 | 1 | 0 | 62.5 | 55.0 | |
Epilepsy | NDD | 2 | 0 | 2 | 0 | 64.0 | ||
Attention deficit hyperactivity disorder | SMI | 2 | 0 | 2 | 0 | 32.5 | ||
Post-traumatic stress disorder | SMI | 2 | 1 | 1 | 0 | 60.0 | 44.0 | |
Schizoaffective depressive disorder | SMI | 2 | 0 | 2 | 0 | 42.5 | ||
