Table 2 Classification of donors by various clinical and neuropathological measurements related to AD diagnosis.

^aCERAD (Consortium to Establish a Registry for Alzheimer’s Disease): Qualitative variable from neuropathological scoring where 1 = normal, 2 = possible AD, 3 = probable AD, 4 = definite AD.
^bBraak: Braak neurofibrillary tangle score from the regional patterns of the density of neurofibrillary tangles across the brain.
^cPlaque mean: The average density of neuritic plaque across five brain regions, i.e., middle frontal gyrus, orbital frontal cortex, superior temporal gyrus, inferior parietal lobule and occipital cortex. Plaque categories are defined by quartile values calculated on distribution of non-zero plaque values.
^dMSSM CDR: Clinical dementia rating available only for MSSM donors where 0 = no dementia, 0.5 = questionable dementia (very mild), 1 = mild dementia, 2 = moderate dementia, 3 = severe dementia, 4 = profound dementia, 5 = terminal dementia.
^eRADC: cogdx: Final consensus cognitive diagnosis available only for RADC donors where 1 = no cognitive impairment, 2 = MCI but no other CI (cognitive impairment), 3 = MCI and another cause of CI, 4 = AD dementia but no other CI, 5 = AD dementia and another cause of CI, 6 = Other dementia.

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