Table 1 Utility of secondary use of pathogen genomic data.
From: Estimating the deferred value of pathogen genomic data for secondary use
Applications | Examples | Requirement for associated metadata* | References |
|---|---|---|---|
Re-use of genomic datasets associated with individual sites | Identification of strains for targeted functional characterisation e.g., evasion of neutralizing antibodies | Minimal | |
Review of suitability of sequence targets for diagnostic testing | Minimal | ||
Development and evaluation of disease surveillance, simulation and prediction models | High | ||
Utilisation of aggregated genomic data | Examination of the international spread of pathogens, relative contribution of their strains and global risk of outbreaks associated with specific pathogens | Minimal | |
Design and evaluation of strain detection algorithms, strain typing systems, specific disease surveillance programs and analysis of their resolution | Moderate | ||
Assessment of impact of public health interventions and documenting specific pathogen elimination | Moderate | ||
Cataloguing mutations conferring drug resistance and adverse outcomes and development and testing of detection algorithms | High | ||
Training and validation of AI models for antimicrobial drug discovery, design and testing | High |
