Table 1 The counts of differential diagnoses and prognoses across each non-CML MN subcategory in real and synthetic cases.
Sub-category | Differential Diagnosis or Prognosis | Count in Real Non-CML MN Cases | Count in Synthetic Cases |
|---|---|---|---|
Total | 9,160 | 5,927 | |
AML | Acute leukemia with adverse prognosis | 257 | 102 |
AML | Acute leukemia with AML-defining mutation/aberration | 67 | 88 |
AML | Acute leukemia with blasts/blast-equivalents above 20% cutoff | 495 | 535 |
AML | Acute leukemia with favorable prognosis | 99 | 33 |
AML | Acute leukemia with intermediate prognosis | 97 | 24 |
AML | Acute leukemia with unfavorable prognosis | 344 | 193 |
AML | Acute leukemic transformation of non-CML myeloid neoplasm | 30 | 369 |
CH | Clonal Cytopenia & Monocytosis of Undetermined Significance | 1 | 4 |
CH | Clonal Cytopenia of Undetermined Significance | 91 | 70 |
CH | Clonal Hematopoiesis of Indeterminate Potential | 59 | 53 |
CH | Clonal Monocytosis of Undetermined Significance | 44 | 5 |
MDS | High-grade MDS with increased blasts (MDS-IB2) | 65 | 35 |
MDS | High-grade MDS (MDS-IB2) with mutated TP53 | 66 | 3 |
MDS | MDS with biallelic TP53 inactivation (MDS-biTP53) | 78 | 6 |
MDS | MDS with increased blasts (MDS-IB1) | 121 | 70 |
MDS | MDS with increased blasts (MDS-IB2) | 92 | 31 |
MDS | MDS with low blasts (MDS-LB) | 966 | 150 |
MDS | MDS with low blasts and SF3B1 mutation (MDS-SF3B1) | 382 | 10 |
MDS/MPN | Accelerated phase of MDS/MPN | 20 | 149 |
MDS/MPN | Chronic Myelomonocytic Leukemia (MD-CMML-1) | 216 | 76 |
MDS/MPN | Chronic Myelomonocytic Leukemia (MD-CMML-2) | 10 | 24 |
MDS/MPN | Chronic Myelomonocytic Leukemia (MP-CMML-1) | 155 | 40 |
MDS/MPN | Chronic Myelomonocytic Leukemia (MP-CMML-2) | 18 | 25 |
MDS/MPN | MDS/MPN with impending progression to accelerated phase | 33 | 59 |
MDS/MPN | MDS/MPN with neutrophilia (atypical CML) | — | 12 |
MDS/MPN | MDS/MPN with SF3B1 mutation and thrombocytosis | 39 | 4 |
MDS/MPN | MDS/MPN, not otherwise specified | 307 | 482 |
MPN | Accelerated phase of MPN | 42 | 126 |
MPN | Chronic Eosinophilic Leukemia | — | 36 |
MPN | Chronic Neutrophilic Leukemia | 24 | 58 |
MPN | Essential Thrombocythemia | 584 | 213 |
MPN | MPN with impending progression to accelerated phase | 46 | 52 |
MPN | MPN, not otherwise specified | — | — |
MPN | Polycythemia vera | 194 | 167 |
MPN | Polycythemia vera with leukocytosis | 170 | 79 |
MPN | Polycythemia vera with superimposed iron deficiency | 10 | 9 |
MPN | Pre-fibrotic stage of Primary Myelofibrosis | 660 | 488 |
MPN | Primary Myelofibrosis | 298 | 281 |
MPN | Triple negative Essential Thrombocythemia | 42 | 118 |
Non-AML | Myeloid neoplasm with adverse prognosis | 715 | 366 |
Non-AML | Myeloid neoplasm with favorable prognosis | 780 | 283 |
Non-AML | Myeloid neoplasm with impending progression to AML | 46 | 270 |
Non-AML | Myeloid neoplasm with poor prognosis | 1,327 | 487 |
Non-AML | Myeloid neoplasm with unfavorable prognosis | 70 | 242 |
