Fig. 5 | Scientific Data

Fig. 5

From: A single-cell transcriptomic dataset profiling traumatic brain injury and NeuroD1-based gene therapy in mice

Fig. 5

Differentially expressed genes and GO pathway enrichment in astrocyte subclusters 3 and 6. (a) Heatmap of top 20 DEGs in astrocytes subcluster 3 between the Normal and TBI + GFP groups. (b) GO enrichment of down-regulated subcluster 3 DEGs in TBI + GFP vs Normal group. (c) Heatmap of top 20 DEGs in astrocytes subcluster 3 between the TBI + GFP and TBI + NeuroD1 groups. (d) GO enrichment of up-regulated subcluster 3 DEGs in TBI + NeuroD1 vs TBI + GFP group. (e) Heatmap of top 20 DEGs in astrocytes subcluster 6 between the Normal and TBI + GFP groups. (f) GO enrichment of down-regulated subcluster 6 DEGs in TBI + GFP vs Normal group. (g) Heatmap of top 20 DEGs in astrocytes subcluster 6 between the TBI + GFP and TBI + NeuroD1 groups. (h) GO enrichment of up-regulated subcluster 6 DEGs in TBI + NeuroD1 vs TBI + GFP group. Color: -log₁₀ adjusted P-value; Size: Gene proportion.

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