Fig. 3

Biological validation of the TCM-induced transcriptomic atlas. (A) Distribution of Pearson’s correlation coefficients for biological replicates. (B) GSEA revealed the potential reversal effects of specific TCMs on disease signatures, including Huang Qi in COAD, Ren Shen in BLCA, and Cang Zhu in BRCA. (C) Statistically significant overlap between the DEGs of TCMs and the known target sets. (D) KEGG pathway enrichment analysis of genes perturbed by Cang Zhu.