Figure 3 | Scientific Reports

Figure 3

From: Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with toxins

Figure 3

C. difficile flagella and caecal inflammation in C57BL/6 tlr5 −/− KO mice. C57BL/6 tlr5 −/− KO mice (n = 10) were infected by oral gavage or not and caeca were collected at the clinical end point day 2 for histology. (A) Representative histology of caecum of healthy uninfected mice (control) with epithelium integrity; (B) R20291 WT-infected mice with mild to moderate edema; (C) R20291 fliC mutant and (D) 630Δerm WT-infected mice with mild to moderate edema (200X magnification). Bar = 200 µm. (E) Inflammation histological scores for individual mice in each group. The horizontal lines represent the mean scores for each group of animals. (F) Individual evaluation criteria of intestinal inflammation. The bars represent the mean scores for each group of animals and standard deviations. *P < 0.01 compared to R20291 WT-infected mice.

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