Figure 4

Heatmaps of significantly DE liver mRNAs as determined by DESeq. 2. (FDR < 0.4) in adult male zebrafish exposed to 5.8 nM DEHP relative to controls. DE genes associated with enriched biological pathways (A) Metabolism of amino acids and derivatives, (B) Metabolic Pathways, (C) Metabolism of Lipids and Lipoproteins, (D) Fatty acid, triacylglycerol, and ketone body metabolism and (E) FOXA2 and FOXA3 transcription factor networks are plotted. Red and blue boxes indicate relative over- and under-expression with respect to a reference which is calculated as the mid-point between the control and exposed groups.