Table 3 DE genes from microarray analysis.

From: Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)

Zebra Entrez Gene ID	Probe ID	Gene Symbol	Gene Name	Human Entrez ID	Human Gene Symbol	Log2 ratio	FC
FOXA2 and FOXA3 transcription factor networks
449677	A_15_P117834	cpt1b	carnitine palmitoyltransferase 1B (muscle)	126129	CPT1C	−5.80	−55.72
30262	A_15_P115731	ins	preproinsulin	3630	INS	−3.61	−12.21
317638	A_15_P105778	igfbp1a	insulin-like growth factor binding protein 1a	3484	IGFBP1	−3.54	−11.63
30262	A_15_P110065	ins	preproinsulin	3630	INS	−3.26	−9.58
140815	A_15_P108996	cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	1050	CEBPA	3.20	9.19
573723	A_15_P101211	acadvl	acyl-Coenzyme A dehydrogenase, very long chain	37	ACADVL	−2.51	−5.70
445118	A_15_P107918	g6pca	glucose-6-phosphatase a, catalytic	2538	G6PC	−2.46	−5.50
322493	A_15_P107681	slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	6514	SLC2A2	2.20	4.59
445118	A_15_P107270	g6pca	glucose-6-phosphatase a, catalytic”	2538	G6PC	−2.06	−4.17
325881	A_15_P112672	f2	coagulation factor II (thrombin)	2147	F2	0.10	1.07
Fatty acid, triacylglycerol, and ketone body metabolism
436636	A_15_P111782	cd36	CD36 antigen	948	CD36	7.88	235.6
768196	A_15_P102657	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	6.01	64.45
386661	A_15_P112389	scd	stearoyl-CoA desaturase (delta-9-desaturase)	79966	SCD5	5.33	40.22
768196	A_15_P107967	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	5.23	37.53
393984	A_15_P119395	aacs	acetoacetyl-CoA synthetase	65985	AACS	5.00	32.00
317738	A_15_P108810	elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)”	79071	ELOVL6	3.68	12.82
317738	A_15_P121489	elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	79071	ELOVL6	3.30	9.85
573723	A_15_P101211	acadvl	acyl-Coenzyme A dehydrogenase, very long chain	37	ACADVL	−2.51	−5.70
393622	A_15_P112797	acsl4a	acyl-CoA synthetase long-chain family member 4a	2182	ACSL4	2.38	5.21
327417	A_15_P109573	hsd17b12a	hydroxysteroid (17-beta) dehydrogenase 12a	51144	HSD17B12	2.20	4.59
Metabolic pathways
445818	A_15_P112409	cthl	cystathionase (cystathionine gamma-lyase), like”	1491	CTH	6.60	97.01
447879	A_15_P114717	zgc:103408	zgc:103408	27231	NMRK2	6.44	86.82
768196	A_15_P102657	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	6.01	64.45
768196	A_15_P107967	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	5.23	37.53
436799	A_15_P115180	atp6v1f	ATPase, H + transporting, V1 subunit F	9296	ATP6V1F	4.47	22.16
393799	A_15_P106842	pycr1	pyrroline-5-carboxylate reductase 1	5831	PYCR1	3.80	13.93
84039	A_15_P108167	bcmo1	beta-carotene 15,15’-monooxygenase 1	53630	BCO1	3.48	11.16
436919	A_15_P111364	ada	adenosine deaminase	100	ADA	3.39	10.48
406651	A_15_P117346	ddc	dopa decarboxylase	1644	DDC	3.31	9.92
406651	A_15_P111461	ddc	dopa decarboxylase	1644	DDC	3.31	9.92
Metabolism of amino acids and derivatives
445818	A_15_P112409	cthl	cystathionase (cystathionine gamma-lyase), like”	1491	CTH	6.60	97.01
393799	A_15_P106842	pycr1	pyrroline-5-carboxylate reductase 1	5831	PYCR1	3.80	13.93
406651	A_15_P117346	ddc	dopa decarboxylase	1644	DDC	3.31	9.92
406651	A_15_P111461	ddc	dopa decarboxylase	1644	DDC	3.31	9.92
572649	A_15_P108171	zgc:112179	zgc:112179	8424	BBOX 1	−2.81	−7.01
114426	A_15_P109191	odc1	ornithine decarboxylase 1	4953	ODC1	2.14	4.41
30665	A_15_P120879	psmb9a	proteasome (prosome, macropain) subunit, beta type, 9a	5698	PSMB9	2.14	4.41
100000775	A_15_P111686	glula	glutamate-ammonia ligase (glutamine synthase) a	2752	GLUL	−2.13	−4.38
321892	A_15_P118448	ckmt1	creatine kinase, mitochondrial 1”	1159	CKMT1B	1.93	3.81
399488	A_15_P101243
	zgc:55813	zgc:55813	6520	SLC3A2	−1.87	−3.66
Metabolism of lipids and lipoproteins
436636	A_15_P111782	cd36	CD36 antigen	948	CD36	7.88	235.57
768196	A_15_P102657	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	6.01	64.45
386661	A_15_P112389	scd	stearoyl-CoA desaturase (delta-9-desaturase)	79966	SCD5	5.33	40.22
768196	A_15_P107967	me1	malic enzyme 1, NADP(+)-dependent, cytosolic	4199	ME1	5.23	37.53
393984	A_15_P119395	aacs	acetoacetyl-CoA synthetase	65985	AACS	5.00	32.00
768298	A_15_P117841	faah2b	fatty acid amide hydrolase 2b	158584	FAAH2	3.83	14.22
317738	A_15_P108810	elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)”	79071	ELOVL6	3.68	12.82
58128	A_15_P109314	fabp7a	fatty acid binding protein 7, brain, a	2173	FABP7	3.56	11.79
58128	A_15_P102880	fabp7a	fatty acid binding protein 7, brain, a	2173	FABP7	3.43	10.78
317738	A_15_P121489	elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	79071	ELOVL6	3.30	9.85

in adult male zebrafish exposed to 5.8 nM DEHP relative to controls associated with enriched biological pathways (Metabolic Pathways; Fatty acid, triacylglycerol, and ketone body metabolism; FOXA2 and FOXA3 transcription factor networks; Metabolism of amino acids and derivatives; Metabolism of Lipids and Lipoproteins). Genes with the greatest fold change difference in DEHP exposed relative to control are presented. An expanded list of DE genes is presented in Supplementary Table S6.

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Table 3 DE genes from microarray analysis.

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