Table 4 Interrelation among AGE, RAGE, TGF- β1, TGF- β1 receptor, BDNF and TrkB expressions in different layers of colon wall.

From: Abnormal expressions of AGEs, TGF-β1, BDNF and their receptors in diabetic rat colon–Associations with colonic morphometric and biomechanical remodeling

layers

Multiple linear regression equation

R values

F values

P values

Independent P

Mucosa

AGE = 0.142 + (0.456 * RAGE) + (0.123 * TGF-β1) + (0.0667 * TGF-β1-R) − (0.316 * BDNF) + (0.190 * TRKB)

0.729

1.132

0.447

RAGE 0.073

TGF-β1 0.705

TGF-β1-R 0.864

BDNF 0.567

TRKB 0.722

RAGE = −0.104 + (0.164 * AGE) + (0.172 * TGF-β1) + (0.337 * TGF-β1-R) + (0.419 * BDNF) − (0.0816 * TRKB)

0.933

6.685

0.029

AGE 0.073

TGF-β1 0.358

TGF-β1-R 0.044

BDNF 0.167

TRKB 0.802

TGF-β1 = 0.143 + (0.253 * AGE) + (0.988 * RAGE) − (0.000207 * TGF-β1-R) − (0.541 * BDNF) − (0.0205 * TRKB)

0.811

1.928

0.244

AGE 0.705

RAGE 0.358

TGF-β1-R 0.069

BDNF 0.491

TRKB 0.979

TGF-β1-R = 0.118 + (0.0965 * AGE) + (1.362 * RAGE) − (0.000145 * TGF-β1) − (0.172 * BDNF) − (0.362 * TRKB)

0.904

4.448

0.064

AGE 0.864

RAGE 0.044

TGF-β1 0.069

BDNF 0.798

TRKB 0.569

BDNF = 0.147 − (0.221 * AGE) + (0.817 * RAGE) − (0.184 * TGF-β1) − (0.0833 * TGF-β1-R) + (0.705 * TRKB)

0.902

4.374

0.066

AGE 0.567

RAGE 0.167

TGF-β1 0.491

TGF-β1-R 0.798

TRKB 0.06

TRKB = −0.0254 + (0.145 * AGE) − (0.173 * RAGE) − (0.00758 * TGF-β1) − (0.191 * TGF-β1-R) + (0.768 * BDNF)

0.876

3.306

0.108

AGE 0.722

RAGE 0.802

TGF-β1 0.979

TGF-β1-R 0.569

BDNF 0.06

Submucosa

AGE = 0.117 − (0.0408 * RAGE) + (0.388 * TGF-β1) + (0.160 * TGF-β1-R) − (0.116 * BDNF) - (0.273 * TRKB)

0.835

2.309

0.19

RAGE 0.089

TGF-β1 0.529

TGF-β1-R 0.73

BDNF 0.709

TRKB 0.389

RAGE = −0.0753 − (0.0986 * AGE) + (0.297 * TGF-β1) + (0.932 * TGF-β1-R) − (0.0793 * BDNF) − (0.0953 * TRKB)

0.893

3.933

0.08

AGE 0.089

TGF-β1 0.76

TGF-β1-R 0.051

BDNF 0.87

TRKB 0.852

TGF-β1 = −0.0617 + (0.216 * AGE) + (0.0686 * RAGE) + (0.395 * TGF-β1-R) + (0.248 * BDNF) − (0.170 * TRKB)

0.921

5.608

0.041

AGE 0.529

RAGE 0.76

TGF-β1-R 0.068

BDNF 0.254

TRKB 0.477

TGF-β1-R = 0.101 + (0.162 * AGE) + (0.392 * RAGE) + (0.720 * TGF-β1) − (0.110 * BDNF) + (0.228 * TRKB)

0.933

6.77

0.028

AGE 0.73

RAGE 0.051

TGF-β1 0.068

BDNF 0.725

TRKB 0.482

BDNF = 0.121 − (0.262 * AGE) − (0.0743 * RAGE) + (1.007 * TGF-β1) − (0.245 * TGF-β1-R) + (0.670 * TRKB)

0.795

1.719

0.283

AGE 0.709

RAGE 0.87

TGF-β1 0.254

TGF-β1-R 0.725

TRKB 0.026

TRKB = 0.0839 − (0.554 * AGE) − (0.0799 * RAGE) − (0.620 * TGF-β1) + (0.455 * TGF-β1-R) + (0.600 * BDNF)

0.841

1.414

0.178

AGE 0.389

RAGE 0.852

TGF-β1 0.477

TGF-β1-R 0.482

BDNF 0.026

Muscle

AGE = 0.0966 + (0.557 * RAGE) + (0.737 * TGF-β1) − (0.0609 * TGF-β1-R) + (0.660 * BDNF) − (1.062 * TRKB)

0.888

3.717

0.088

RAGE 0.037

TGF-β1 0.374

TGF-β1-R 0.931

BDNF 0.452

TRKB 0.204

RAGE = 0.204 + (0.287 * AGE) − (0.140 * TGF-β1) + (0.631 * TGF-β1-R) − (0.614 * BDNF) + (0.397 * TRKB)

0.929

6.321

0.032

AGE 0.037

TGF-β1 0.745

TGF-β1-R 0.029

BDNF 0.319

TRKB 0.536

TGF-β1 = 0.0415 + (0.449 * AGE) − (0.165 * RAGE) + (0.409 * TGF-β1-R) − (0.565 * BDNF) + (0.678 * TRKB)

0.895

4.029

0.076

AGE 0.374

RAGE 0.745

TGF-β1-R 0.044

BDNF 0.406

TRKB 0.315

TGF-β1-R = -0.000233 − (0.0268 * AGE) + (0.539 * RAGE) + (0.296 * TGF-β1) − (0.0810 * BDNF) + (0.194 * TRKB)

0.912

4.942

0.052

AGE 0.931

RAGE 0.029

TGF-β1 0.044

BDNF 0.893

TRKB 0.747

BDNF = 0.239 + (0.178 * AGE) − (0.321 * RAGE) − (0.250 * TGF-β1) − (0.0496 * TGF-β1-R) + (0.826 * TRKB)

0.926

5.984

0.036

AGE 0.452

RAGE 0.319

TGF-β1 0.406

TGF-β1-R 0.893

TRKB 0.024

TRKB = −0.0409 − (0.281 * AGE) + (0.204 * RAGE) + (0.295 * TGF-β1) + (0.117 * TGF-β1-R) + (0.812 * BDNF)

0.887

3.705

0.088

AGE 0.204

RAGE 0.536

TGF-β1 0.315

TGF-β1-R 0.747

BDNF 0.024

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