Table 2 Allelic Distribution. Logistic regression analysis of significant variants of genes in our study, adjusted for age, gender and BMI.
VARIANT | rs9419958 | rs4783704 | rs16847897 | rs10936599 | rs74019828 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
NEAREST GENE (VARIANT) | OBFC1 | TERF2 | TERC | TERC | CSNK2A2 | |||||
POLYMORPHISM (ref/alt-GRCh38/hg38) | T/C | C/T | G/C | C/T | G/A | |||||
ANCESTRAL ALLELE | T | C | C | C | G | |||||
ALLELE DISTRIBUTION | T | C | C | T | G | T | C | A | G | |
CASES (n = 682) | 0.04 | 0.96 | 0.13 | 0.87 | 0.43 | 0.57 | 0.16 | 0.84 | 0.07 | 0.93 |
CONTROLS (n = 672) | 0.07 | 0.93 | 0.16 | 0.84 | 0.38 | 0.62 | 0.27 | 0.73 | 0.15 | 0.85 |
ALLELIC ODDS RATIO (95% CI) | 1.98 (1.38–2.85) | 1.32 (1.06–1.65) | 1.23 (1.05–1.44) | 1.76 (1.46–2.12) | 2.10 (1.63–2.72) | |||||
RISK ALLELE | C | C | C | C | G | |||||
GENOTYPIC MODEL | Recessive (CC vs TT + CT) | Recessive CC vs TT + CT) | Dominant (CC + GC vs GG) | Recessive (CC vs TT + CT) | Recessive (GG vs AA + GA) | |||||
p-VALUE* | 5.8E-5 | 0.001 | 2.4E-9 | 1.63E-12 | 6.57E-9 | |||||
ODDS RATIO (95% CI) | 2.30 (1.53–3.46) | 1.52 (1.17–1.97) | 2.23 (1.71–2.90) | 2.44 (1.90–3.12) | 2.37 (1.77–3.18) | |||||
