Table 2 Comparison of clinical course between early-onset idiopathic chronic pancreatitis(a) and late-onset idiopathic chronic pancreatitis(a) in different cut-offs of age at onset of idiopathic chronic pancreatitis.

From: Classification of Early-Onset and Late-Onset Idiopathic Chronic Pancreatitis Needs Reconsideration

Items

EOICP15

N = 180

LOICP15

N = 1453

EOICP25

N = 412

LOICP25

N = 1221

EOICP35

N = 685

LOICP35

N = 948

EOICP45

N = 1045

LOICP45

N = 588

EOICP55

N = 1327

LOICP55

N = 306

EOICP65

N = 1527

LOICP65

N = 106

Male sex

86 (47.8%)

945 (65.0%)§

216 (52.4%)

815 (66.7%)§

383 (55.9%)

648 (68.4%)§

642 (61.4%)

389 (66.2%)#

824 (62.1%)

207 (67.6%)#

959 (62.8%)

72 (67.9%)#

Age at the onset of CP, y*

10.401 (6.701, 13.019)

40.441 (29.319, 52.408)§

16.141 (11.256, 20.544)

44.030 (35.848, 55.123)§

22.022 (14.669, 28.788)

48.827 (40.990, 57.288)§

28.997 (18.944, 37.559)

55.458 (49.601, 62.158)§

33.619 (21.641, 43.219)

61.918 (57.651, 68.899)§

37.088 (23.915, 47.943)

70.610 (68.786, 73.358)§

Age at the diagnosis of CP, y*

16.380 (12.799, 22.129)

45.225 (35.595, 56.329)§

20.966 (16.362, 27.880)

48.269 (39.482, 58.143)§

28.266 (19.758, 34.840)

51.510 (44.251, 60.327)§

35.260 (24.311, 42.115)

58.169 (52.373, 63.864)§

38.885 (27.567, 47.904)

63.173 (59.526, 70.525)§

41.449 (29.770, 51.449)

72.343 (69.559, 75.422)§

Initial manifestations

 

§

 

§

 

§

 

§

 

§

 

#

Abdominal pain

176 (97.8%)

1170 (80.5%)

384 (93.2%)

962 (78.8%)

609 (88.9%)

737 (77.7%)

895 (85.6%)

451 (76.7%)

1125 (84.8%)

221 (72.2%)

1261 (82.6%)

85 (80.2%)

Endocrine/Exocrine dysfunction

4 (2.2%)

174 (12.0%)

18 (4.4%)

160 (13.1%)

49 (7.2%)

129 (13.6%)

106 (10.1%)

72 (12.2%)

138 (10.4%)

40 (13.1%)

168 (11.0%)

10 (9.4%)

Others

0 (0.0%)

109 (7.5%)

10 (2.4%)

99 (8.1%)

27 (3.9%)

82 (8.6%)

44 (4.2%)

65 (11.1%)

64 (4.8%)

45 (14.7%)

98 (6.4%)

11 (10.4%)

Pancreatic stones†

167 (92.8%)

1025 (70.5%)§

374 (90.8%)

818 (67.0%)§

596 (87.0%)

596 (62.9%)§

858 (82.1%)

334 (56.8%)§

1039 (78.3%)

153 (50.0%)§

1143 (74.9%)

49 (46.2%)§

Time between onset and pancreatic stone*

7.419

(2.499, 13.756)

2.255

(0.166,7.048)§

5.192 (1.419, 13.008)

2.003 (0.134, 6.332)§

4.430 (1.000, 11.112)

1.499 (0.061, 5.751)§

3.745 (0.832, 9.882)

0.666 (0.000, 4.836)§

3.255

(0.501, 9.006)

0.419

(0.000, 3.586)§

3.002 (0.337, 8.510)

0.022 (0.000, 2.436)§

DM

17 (9.4%)

413 (28.4%)§

52 (12.6%)

378 (31.0%)§

129 (18.8%)

301 (31.8%)§

251 (24.0%)

179 (30.4%)||

354 (26.7%)

76 (24.8%)#

405 (26.5%)

25 (23.6%)#

Time between onset and DM*

21.014

(2.252, 26.141)

1.416 (0.000, 7.170)§

16.011 (1.960, 23.012)

1.086 (0.000, 5.587)§

9.008 (0.373, 16.597)

0.753 (0.000, 3.822)§

3.323 (0.000, 10.589)

0.334 (0.000, 2.507)§

2.463

(0.000, 8.691)

0.000

(0.000, 0.979)§

2.003 (0.000, 7.838)

0.000 (0.000, 0.188)§

Steatorrhea

24 (13.3%)

315 (21.7%)||

72 (17.5%)

267 (21.9%)#

151 (22.0%)

188 (19.8%)#

239 (22.9%)

100 (17.0%)||

292 (22.0%)

47 (15.4%)

334 (21.9%)

5 (4.7%)§

Time between onset and steatorrhea*

12.595

(4.503, 21.014)

1.085

(0.000, 9.093)§

7.882 (1.416, 20.014)

1.000 (0.000, 8.005)§

5.005 (0.011, 13.841)

0.249 (0.000, 6.232)§

3.249 (0.000, 11.425)

0.162 (0.000, 5.175)§

2.463

(0.000, 10.443)

0.112

(0.000, 1.085)§

1.671 (0.000, 9.614)

6.838 (3.921, 8.501)#

Biliary stricture

14 (7.8%)

245 (16.9%)||

26 (6.3%)

233 (19.1%)§

49 (7.2%)

210 (22.2%)§

116 (11.1%)

143 (24.3%)§

172 (13.0%)

87 (28.4%)§

225 (14.7%)

34 (32.1%)§

Time between onset and CBD stenosis*

27.618

(12.258, 37.319)

1.501

(0.167, 6.145)§

21.016 (9.340, 31.628)

1.211 (0.167, 6.014)§

10.419 (4.332, 24.014)

0.916 (0.077, 4.444)§

4.332 (0.918, 10.982)

0.748 (0.077, 3.332)§

3.337

(0.427, 9.074)

0.299

(0.011, 2.137)§

2.167 (0.241, 8.188)

0.299 (0.127, 2.501)||

Pancreatic pseudocyst

17 (9.4%)

223 (15.3%)#

41 (10.0%)

199 (16.3%)||

89 (13.0%)

151 (15.9%)#

146 (14.0%)

94 (16.0%)#

186 (14.0%)

54 (17.6%)#

226 (14.8%)

14 (13.2%)#

Time between onset and pseudocyst formation*

2.836

(0.656, 8.838)

2.164

(0.290, 5.836)#

5.068 (1.238, 8.922)

1.608 (0.290, 5.249)||

4.737 (1.000, 8.496)

1.025 (0.290, 3.975)§

3.874 (0.331, 7.258)

1.000 (0.173, 3.605)||

3.501

(0.414, 7.258)

1.000

(0.052, 2.422)§

2.389 (0.329, 6.334)

1.000 (0.000, 2.558)||

Death

0 (0.0%)

57 (3.9%)||

4 (1.0%)

53 (4.3%)§

4 (0.6%)

53 (5.6%)§

12 (1.1%)

45 (7.7%)§

25 (1.9%)

32 (10.5%)§

38 (2.5%)

19 (17.9%)§

Pancreatic cancer

0 (0.0%)

18 (1.2%)#

2 (0.5%)

16 (1.3%)#

2 (0.3%)

16 (1.7%)||

7 (0.7%)

11 (1.9%)

14 (1.1%)

4 (1.3%)#

18 (1.2%)

0 (0.0%)#

Morphology of MPD‡

 

§

 

§

 

§

 

§

 

§

 

§

Pancreatic stone alone

67 (37.2%)

388 (26.7%)

137 (33.3%)

318 (26.0%)

217 (31.7%)

238 (25.1%)

303 (29.0%)

152 (25.9%)

379 (28.6%)

76 (24.8%)

433 (28.4%)

22 (20.8%)

MPD stenosis alone

38 (21.1%)

459 (31.6%)

79 (19.2%)

418 (34.2%)

144 (21.0%)

353 (37.2%)

253 (24.2%)

244 (41.5%)

355 (26.8%)

142 (46.4%)

442 (28.9%)

55 (51.9%)

MPD stenosis and stone

68 (37.8%)

451 (31.0%)

177 (43.0%)

342 (28.0%)

279 (40.7%)

240 (25.3%)

403 (38.6%)

116 (19.7%)

470 (35.4%)

49 (16.0%)

500 (32.7%)

19 (17.9%)

Complex pathologic changes

7 (3.9%)

155 (10.7%)

19 (4.6%)

143 (11.7%)

45 (6.6%)

117 (12.3%)

86 (8.2%)

76 (12.9%)

123 (9.3%)

39 (12.7)

152 (10.0%)

10 (9.4%)

Type of pain

 

§

 

§

 

§

 

§

 

§

 

Recurrent acute pancreatitis

50 (27.8%)

437 (29.8%)

138 (33.5%)

349 (28.6%)

223 (32.6%)

264 (27.8%)

318 (30.4%)

169 (28.7%)

403 (30.4%)

84 (27.5%)

449 (29.4%)

38 (35.8%)

Recurrent pain

43 (23.9%)

471 (32.4%)

102 (24.8%)

412 (33.7%)

174 (25.4%)

340 (35.9%)

292 (27.9%)

222 (37.8%)

392 (29.5%)

122 (39.9%)

472 (30.9%)

42 (39.6%)

Recurrent acute pancreatitis and pain

75 (41.7%)

344 (23.7%)

144 (35.0%)

275 (22.5%)

223 (32.6%)

196 (20.7%)

317 (30.3%)

102 (17.3%)

381 (28.7%)

38 (12.4%)

406 (26.6%)

13 (12.3%)

Chronic pain

11 (6.1%)

68 (4.7%)

19 (4.6%)

60 (4.9%)

33 (4.8%)

46 (4.9%)

50 (4.8%)

29 (4.9%)

381 (28.7%)

38 (12.4%)

73 (4.8%)

6 (5.7%)

Without pain

1 (0.6%)

133 (9.2%)

9 (2.2%)

125 (10.2%)

32 (4.7%)

102 (10.8%)

68 (6.5%)

66 (11.2%)

85 (6.4%)

49 (16.0%)

127 (8.3%)

7 (6.6%)

  1. CP = chronic pancreatitis, CBD = common biliary stricture, DM = diabetes mellitus, EOICP = early-onset idiopathic chronic pancreatitis, ICP = idiopathic chronic pancreatitis, LOICP = late-onset idiopathic chronic pancreatitis, MPD = main pancreatic duct, NS = nonsignificant.
  2. *Median (interquartile ranges).
  3. †Pancreatic calcifications were also regarded as stones that are located in branch pancreatic duct or ductulus.
  4. ‡MPD was classified as four types: pancreatic stone alone, MPD stenosis alone, MPD stenosis combined with stone and complex pathologic changes (patients with stricture, stones and also ductal dilatation in the body/tail area).
  5. §Significant in comparison with EOICPn- at P < 0.001.
  6. ||Significant in comparison with patients with EOICPn- at P < 0.01.
  7. Significant in comparison with patients with EOICPn- at P < 0.05.
  8. #Non-significant in comparison with patients with EOICPn- at P > 0.05.
Back to article page