Table 2 List of the 72 significantly changed proteins during controlled ovarian hyperstimulation, P < 0.01.

Down-regulated proteins

Alpha-1-acid glycoprotein 1

ORM1

− 0.40

< 0.0001

Apolipoprotein E

APOE

− 0.37

< 0.0001

Haptoglobin; Haptoglobin alpha chain; Haptoglobin beta chain

HP

-0.36

< 0.0001

Serum amyloid A-4 protein

SAA2–SAA4; SAA4

− 0.35

0.0063

Ig lambda chain V–V region DEL

NA

− 0.34

0.0050

Coagulation factor V; Coagulation factor V heavy chain; Coagulation factor V light chain

F5

− 0.33

0.0005

Proteoglycan 4; Proteoglycan 4 C-terminal part

PRG4

− 0.30

0.0045

Tetranectin

CLEC3B

− 0.27

< 0.0001

NA

IGKV1–17

− 0.27

< 0.0001

NA

IGLV3–9

− 0.26

0.0087

C4b-binding protein alpha chain

C4BPA

− 0.25

< 0.0001

Plasma protease C1 inhibitor

SERPING1

− 0.25

< 0.0001

Complement component C6

C6

− 0.23

< 0.0001

Antithrombin-III

SERPINC1

− 0.23

< 0.0001

Glutathione peroxidase; Glutathione peroxidase 3

GPX3

− 0.22

0.0015

Carboxylic ester hydrolase; Cholinesterase

BCHE

− 0.21

0.0040

Alpha-1-acid glycoprotein 2

ORM2

− 0.20

0.0069

Vitamin K-dependent protein S

PROS1

− 0.19

< 0.0001

C4b-binding protein beta chain

C4BPB

− 0.19

0.0017

NA

IGLV1–44

− 0.17

0.0006

Extracellular matrix protein 1

ECM1

− 0.17

0.0005

Immunoglobulin J chain

IGJ; JCHAIN

− 0.17

< 0.0001

NA

IGHV3–72

− 0.17

0.0004

Transthyretin

TTR

− 0.17

< 0.0001

Ig lambda-2 chain C regions; Ig lambda-3 chain C regions

IGLC3; IGLC2

− 0.16

0.0001

Apolipoprotein B-100; Apolipoprotein B-48

APOB

− 0.16

0.0009

Gelsolin

GSN

− 0.15

< 0.0001

Complement C1q subcomponent subunit B

C1QB

− 0.15

0.0007

Complement factor I; Complement factor I heavy chain; Complement factor I light chain

CFI

− 0.15

< 0.0001

Apolipoprotein D

APOD

− 0.15

0.0015

Apolipoprotein C-I; Truncated apolipoprotein C-I

APOC1

− 0.14

0.0038

Histidine-rich glycoprotein

HRG

− 0.14

0.0007

Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form

CD14

− 0.13

0.0013

N-Acetylmuramoyl-l-alanine amidase

PGLYRP2

− 0.13

0.0006

Apolipoprotein A-II; Proapolipoprotein A-II; Truncated apolipoprotein A-II

APOA2

− 0.12

0.0067

Alpha-2-antiplasmin

SERPINF2

− 0.11

< 0.0001

NA

IGKV3–11

− 0.11

0.0036

Complement C1q subcomponent subunit A

C1QA

− 0.11

0.0097

Complement component C7

C7

− 0.11

0.0008

Ig gamma-1 chain C region

IGHG1

− 0.11

0.0009

Complement component C8 gamma chain

C8G

− 0.10

0.0087

Alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin His-Pro-less

SERPINA3

− 0.10

0.0003

Complement C4-B; Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain

C4B

− 0.08

0.0012

Complement factor B; Complement factor B Ba fragment; Complement factor B Bb fragment

CFB

− 0.06

0.0081

Up-regulated proteins

Inter-alpha-trypsin inhibitor heavy chain H4; 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4

ITIH4

0.11

0.0002

Apolipoprotein A-I; Proapolipoprotein A-I; Truncated apolipoprotein A-I

APOA1

0.13

0.0002

Kininogen-1; Kininogen-1 heavy chain; T-kinin; Bradykinin; Lysyl-bradykinin; Kininogen-1 light chain; Low molecular weight growth-promoting factor

KNG1

0.14

0.0008

Fibulin-1

FBLN1

0.17

0.0018

Fibrinogen gamma chain

FGG

0.17

< 0.0001

Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B

AHSG

0.21

< 0.0001

Fibrinogen alpha chain; Fibrinopeptide A; Fibrinogen alpha chain

FGA

0.23

< 0.0001

Fibrinogen beta chain; Fibrinopeptide B; Fibrinogen beta chain

FGB

0.23

< 0.0001

Alpha-1-antitrypsin; Short peptide from AAT

SERPINA1

0.27

< 0.0001

Thyroxine-binding globulin

SERPINA7

0.27

< 0.0001

Vitamin D-binding protein

GC

0.27

< 0.0001

Hyaluronan-binding protein 2; Hyaluronan-binding protein 2 50 kDa heavy chain;Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form

HABP2

0.28

< 0.0001

Ceruloplasmin

CP

0.29

< 0.0001

von Willebrand factor; von Willebrand antigen 2

VWF

0.33

0.0002

Vitronectin; Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B

VTN

0.39

< 0.0001

Corticosteroid-binding globulin

SERPINA6

0.42

< 0.0001

NA

NA

0.55

0.0007

Lipopolysaccharide-binding protein

LBP

0.63

< 0.0001

Fetuin-B

FETUB

0.67

< 0.0001

Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed

ACTB

0.91

0.0031

Angiotensinogen;Angiotensin-1;Angiotensin-2;Angiotensin-3;Angiotensin-4;Angiotensin 1–9;Angiotensin 1–7;Angiotensin 1–5;Angiotensin 1–4

AGT

1.12

< 0.0001

Sex hormone-binding globulin

SHBG

1.54

< 0.0001

Pregnancy zone protein

PZP

1.83

< 0.0001

Hemoglobin subunit beta;LVV-hemorphin-7;Spinorphin

HBB

1.88

< 0.0001

Hemoglobin subunit alpha

HBA1

1.89

< 0.0001

Heat shock cognate 71 kDa protein

HSPA8

2.35

0.0063

78 kDa glucose-regulated protein

HSPA5

3.65

0.0027

Carbamoyl-phosphate synthase [ammonia], mitochondrial

CPS1

5.97

< 0.0001