Table 5 The relationship between validated ratios, scores and survival in patients undergoing surgery for rectal cancer (n = 413).

TNM stage

I (n = 88)

0.622 (0.564–0.680)

0.596 (0.542–0.651)

II (n = 161)

2.05 (1.06–3.98)

0.034

1.85 (0.89–3.85)

0.098

1.39 (0.89–2.15)

0.144

1.24 (0.75–2.05)

0.395

III (n = 164)

3.22 (1.70–6.13)

 < 0.001

2.64 (1.29–5.40)

0.008

1.89 (1.23–2.91)

0.004

1.65 (1.01–2.69)

0.045

Type of surgery

Open (n = 343) vs laparoscopic (n = 70)

0.575 (0.517–0.634)

2.51 (1.16–5.41)

0.019

2.05 (0.94–4.67)

0.070

0.614 (0.560–0.667)

2.48 (1.30–4.72)

0.006

1.84 (0.95–3.60)

0.073

Time to surgery

1997–2004 (n = 129)

0.608 (0.547–0.669)

0.698 (0.647–0.749)

2005–2015 (n = 284)

0.76 (0.52–1.10)

0.146

0.76 (0.49–1.18)

0.215

0.64 (0.47–0.87)

0.005

0.74 (0.53–1.05)

0.094

Margin involvement

R0 (n = 364)

0.564 (0.499–0.628)

0.532 (0.475–0.588)

R1 (n = 45)

2.83 (1.79–4.48)

 < 0.001

2.59 (1.59–4.21)

 < 0.001

1.88 (1.26–2.82)

0.002

1.76 (1.14–2.72)

0.010

Surgical complication

No (n = 209)

0.556 (0.490–0.622)

0.531 (0.472–0.590)

Yes (n = 160)

1.61 (1.09–2.38)

0.017

1.39 (0.94–2.07)

0.104

1.50 (1.10–2.04)

0.010

1.49 (1.07–2.07)

0.017

NLR/ NLS

NLR < 3 (n = 209)

0.525 (0.463–0.587)

0.595 (0.540–0.649)

NLR 3–5 (n = 130)

1.25 (0.83–1.89)

0.288

1.18 (0.76–1.84)

0.465

1.44 (1.04–1.99)

0.027

1.45 (1.02–2.05)

0.038

NLR > 5 (n = 74)

1.17 (0.71–1.92)

0.540

0.82 (0.47–1.44)

0.494

1.68 (1.17–2.40)

0.005

1.32 (0.87–1.98)

0.188

NLS 0 (n = 217)

0.565 (0.503–0.627)

0.585 (0.530–0.640)

NLS 1 (n = 177)

1.49 (1.02–2.17)

0.040

1.40 (0.92–2.12)

0.115

1.39 (1.04–1.87)

0.025

1.33 (0.97–1.84)

0.077

NLS 2 (n = 19)

1.94 (0.88–4.28)

0.101

1.73 (0.76–3.95)

0.191

2.52 (1.46–4.37)

0.001

2.21 (1.22–4.03)

0.009

PLR/ PLS

PLR ≤ 150 (n = 151)

0.535 (0.468–0.603)

0.532 (0.472–0.592)

PLR > 150 (n = 210)

1.24 (0.81–1.89)

0.324

1.16 (0.73–1.83)

0.536

1.15 (0.83–1.58)

0.403

1.08 (0.76–1.53)

0.676

PLS 0 (n = 187)

0.566 (0.499–0.634)

0.594 (0.535–0.653)

PLS 1 (n = 164)

1.60 (1.06–2.43)

0.027

1.36 (0.87–2.14)

0.183

1.56 (1.13–2.15)

0.007

1.36 (0.96–1.94)

0.083

PLS 2 (n = 10)

1.24 (0.38–4.01)

0.721

1.06 (0.32–3.57)

0.113

2.01 (0.96–4.18)

0.063

1.47 (0.62–3.50)

0.381

LMR/ LMS

LMR ≥ 2.4 (n = 133)

0.559 (0.445–0.673)

0.589 (0.505–0.673)

LMR < 2.4 (n = 85)

2.22 (1.22–4.04)

0.009

2.08 (1.13–3.845)

0.019

1.78 (1.09–2.91)

0.021

1.73 (1.05–2.83)

0.031

LMS 0 (n = 105)

0.612 (0.517–0.706)

0.592 (0.492–0.692)

LMS 1 (n = 106)

1.97 (1.03–3.74)

0.039

1.90 (0.99–3.63)

0.054

1.97 (1.16–3.37)

0.013

2.01 (1.17–3.44)

0.011

LMS 2 (n = 7)

2.60 (0.59–11.47)

0.208

2.38 (0.54–10.59)

0.255

2.47 (0.73–8.35)

0.147

2.51 (0.74–8.51)

0.139

NPS

NPS 0 (n = 320)

0.538 (0.468–0.607)

0.569 (0.509–0.630)

NPS 1 (n = 33)

2.23 (1.28–3.88)

0.005

1.72 (0.92–3.22)

0.087

2.03 (1.30–3.16)

0.002

1.97 (1.22–3.16)

0.005

NPS 2 (n = 8)

0.58 (0.08–4.13)

0.582

0.70 (0.10–5.07)

0.727

2.55 (1.19–5.48)

0.016

2.40 (0.97–5.94)

0.058

CAR/ mGPS

CAR ≤ 0.22 (n = 298)

0.554 (0.491–0.617)

0.549 (0.494–0.605)

CAR > 0.22 (n = 115)

1.46 (0.99–2.14)

0.053

1.14 (0.75–1.75)

0.541

1.26 (0.94–1.70)

0.127

1.13 (0.81–1.56)

0.483

mGPS 0 (n = 314)

0.577 (0.513–0.641)

0.553 (0.497–0.608)

mGPS 1 (n = 58)

1.20 (0.71–2.03)

0.498

1.11 (0.64–1.94)

0.701

1.03 (0.69–1.54)

0.879

1.06 (0.69–1.61)

0.796

mGPS 2 (n = 41)

2.59 (1.61–4.17)

 < 0.001

2.09 (1.17–3.72)

0.012

1.79 (1.19–2.69)

0.005

1.56 (0.96–2.53)

0.074