Table 1 Genes involved in lipid metabolism that are downregulated in the substantia nigra pars compacta of PD patients compared with control subjects.

From: Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

Pathway

Human genes

Adjusted P-value

Phospholipid metabolism

ARF3, ASAH1, CERS6, CERK, PITPNB, PIK3R3, OCRL, MTMR4, PLD3, AGPAT4, INPP4A, PTDSS1, COL4A3BP, STS, SYNJ1, VAPB, OSBP, PI4KA, PIP5K1B, GPD1L, PI4K2A, CDS2

0.0003

Lipid and lipoprotein metabolism

ARF3, IDI1, ASAH1, ALAS1, CERK, PITPNB, PIK3R3, HMGCR, MTMR4, PLD3, AGPAT4, PTDSS1, COL4A3BP, STS, OXCT1, OSBP, PIP5K1B, PRKACB, CERS6, HMGCS1, SRD5A1, OCRL, MED7, INPP4A, ACLY, SYNJ1, VAPB, AGPS, PI4KA, GPD1L, PI4K2A, CDS2

0.0180

Sphingolipid metabolism

COL4A3BP, ASAH1, STS, CERS6, CERK, VAPB, OSBP, B4GALT6

0.0488

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