Table 3 In vitro activity of compounds 1–3 against T. b. rhodesiense (STIB900) and P. falciparum (NF54) and cytotoxicity in L6 Cells.

From: Unusual derivatives from Hypericum scabrum

Compound

IC50 (μM)a

T. b. rhodesiense

P. falciparum

L6 cells

1

3.07 ± 0.77; 11.07b

2.25 ± 0.10; 15.10b

33.98 ± 2.16

2

> 100.0

> 100.0

> 100.0

3

> 100.0

21.14 ± 1.60; 17.50b

> 100.0

Melarsoprol

0.04

  

Chloroquine

 

0.01

 

Podophyllotoxin

  

0.009

  1. aAverage of at least two independents assays.
  2. bSelectivity index (SI): IC50 in L6 cells divided by IC50 in the titled parasitic strain.
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