Table 3 Comparison of intraretinal layer thickness between worse and better eye in pediatric and juvenile craniopharyngioma patients and healthy controls.

From: Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma

 

Worse eye (N = 16)

Better eye (N = 16)

Controls (N = 20)

p-value (worse vs better)

p-value (worse vs control)

p-value (better vs control)

Superior quadrant (μm)

 

RNFL

19.03 ± 5.58

23.59 ± 5.03

32.03 ± 2.75

0.2598*

 < 0.0001*

 < 0.0001‡

GCL

27.72 ± 6.82

33.13 ± 7.54

46.60 ± 2.51

1.0000†

 < 0.0001‡

 < 0.0001‡

IPL

25.00 ± 3.85

27.94 ± 4.15

37.38 ± 2.42

1.0000†

 < 0.0001‡

 < 0.0001‡

INL

41.44 ± 4.42

40.88 ± 4.41

39.05 ± 3.32

1.0000†

1.0000‡

1.0000‡

OPL

34.78 ± 6.97

33.47 ± 8.03

34.70 ± 8.17

1.0000†

1.0000*

1.0000*

ONL

60.50 ± 12.44

60.22 ± 11.90

60.43 ± 10.87

1.0000†

1.0000‡

1.0000‡

PRL

67.28 ± 2.86

67.03 ± 2.69

67.03 ± 2.45

1.0000*

1.0000‡

1.0000‡

Inferior quadrant (μm)

RNFL

21.19 ± 6.05

25.50 ± 4.51

30.73 ± 1.95

0.2582†

 < 0.0001‡

0.0015‡

GCL

28.53 ± 6.44

34.84 ± 6.39

46.58 ± 2.49

0.1702†

 < 0.0001*

 < 0.0001*

IPL

25.00 ± 3.85

27.94 ± 4.15

36.88 ± 2.25

0.1272†

 < 0.0001‡

 < 0.0001‡

INL

40.91 ± 5.20

38.28 ± 3.11

38.88 ± 3.28

0.5905†

1.0000*

1.0000*

OPL

30.28 ± 6.47

30.31 ± 4.77

30.78 ± 5.54

1.0000*

1.0000*

1.0000*

ONL

58.03 ± 8.12

58.69 ± 9.29

60.3 ± 8.40

1.0000†

1.0000‡

1.0000‡

PRL

66.47 ± 3.27

66.28 ± 2.73

66.3 ± 2.86

1.0000*

1.0000*

1.0000*

Nasal quadrant (μm)

RNFL

18.72 ± 4.22

22.06 ± 5.36

34.05 ± 3.06

0.8604†

 < 0.0001‡

 < 0.0001‡

GCL

23.59 ± 6.91

26.03 ± 8.69

47.33 ± 2.32

1.0000*

 < 0.0001*

 < 0.0001*

IPL

22.16 ± 4.40

23.59 ± 5.75

37.50 ± 1.44

1.0000*

 < 0.0001*

 < 0.0001*

INL

41.06 ± 3.30

39.56 ± 4.08

38.03 ± 2.84

1.0000†

0.1521‡

1.0000‡

OPL

30.81 ± 3.82

29.66 ± 2.95

29.53 ± 3.44

1.0000†

1.0000‡

1.0000‡

ONL

64.94 ± 8.33

65.53 ± 8.29

66.48 ± 6.27

1.0000†

1.0000‡

1.0000‡

PRL

68.09 ± 2.73

67.94 ± 2.63

67.88 ± 2.28

1.0000†

1.0000‡

1.0000‡

Temporal quadrant (μm)

RNFL

16.66 ± 1.86

17.16 ± 1.31

17.35 ± 1.03

1.0000*

1.0000*

1.0000‡

GCL

28.59 ± 9.93

37.59 ± 8.06

44.45 ± 2.66

0.3649*

 < 0.0001‡

0.0094*

IPL

28.44 ± 5.84

33.28 ± 4.29

37.55 ± 1.90

0.2092†

 < 0.0001‡

0.0082*

INL

36.84 ± 2.91

36.06 ± 2.11

37.93 ± 2.48

1.0000†

1.0000‡

1.0000‡

OPL

28.81 ± 2.91

30.22 ± 4.54

30.53 ± 3.30

1.0000*

1.0000*

1.0000*

ONL

63.22 ± 7.88

58.94 ± 9.33

62.98 ± 6.54

0.2300†

1.0000‡

1.0000‡

PRL

67.53 ± 3.09

66.84 ± 2.73

67.65 ± 2.45

1.0000*

1.0000‡

1.0000‡

  1. Significant values are indicated in bold.
  2. N numbers, RNFL retinal nerve fiber layer, GCL ganglion cell layer ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, PRL photoreceptor layer.
  3. *P-values obtained by the Wilcoxon signed rank test and Bonferroni’s correction multiplied by 28.
  4. †P-values obtained by the paired t-test and Bonferroni’s correction multiplied by 28.
  5. ‡P-values obtained by T-test and Bonferroni’s correction multiplied by 28.
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