Table 2 Linear regression analysis to elucidate the factors associated with preoperative levels of serum HMGB1.

From: Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients

Variables

β

t

P-value

Univariate analysis

Age, years

− 0.165

− 2.04

0.043*

Sex, male

0.127

1.57

0.118

Smoking history, pack-years

0.243

3.06

0.003*

VC, %predicted

− 0.179

− 2.23

0.027*

FVC, % predicted

− 0.118

− 1.45

0.149

FEV1, % predicted

− 0.144

− 1.78

0.077

FEV1/FVC, %

0.049

0.60

0.550

DLco, % predicted

− 0.099

− 1.22

0.226

ILD pattern, UIP

0.042

0.52

0.603

Preoperative steroid use, + 

− 0.008

− 0.10

0.917

pStage, I/II/III

0.017

0.20

0.838

Primary tumor size, mm

0.139

1.72

0.087

CEA, ng/mL

0.016

0.19

0.848

KL-6, U/mL

0.013

0.16

0.876

FDG uptake of primary tumor, SUVmax

0.116

1.40

0.164

Multivariate analysis#

Age, years

− 0.170

− 2.19

0.030*

Smoking history, pack-years

0.210

2.62

0.010*

VC, % predicted

− 0.164

− 2.08

0.040*

  1. AE-ILD acute exacerbation; CEA carcinoembryonic antigen; DLco diffusing capacity for carbon monoxide; FDG fluorodeoxyglucose; FEV1 forced expiratory volume in one second; FVC forced vital capacity; HMGB1 high-mobility group box 1; ILD interstitial lung disease; KL-6 Krebs von den Lungen 6; SUV standard uptake value; UIP usual interstitial pneumonia; VC vital capacity.
  2. *P < 0.05 Linear regression model.
  3. #Confounders with a p-value < 0.05 according to the univariate analysis, were included.
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