Table 4 Patient characteristics based on the type of surgical intervention.

From: Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients

 

Sublobar resection#

Lobectomy

P-value

Subjects, n (%)

75 (49.3)

77 (50.7)

 

Age, years

74.4 ± 7.2

71.5 ± 7.5

0.023*

Sex, male/female

65/10

61/16

0.221

Smoking history, pack-years

46 (30.8–71.3)

50 (30.0–65.3)

0.883

VC, % predicted

88.6 ± 19.2

92.9 ± 12.4

0.105

FVC, % predicted

86.5 ± 17.6

89.3 ± 12.4

0.262

FEV1, % predicted

86.7 ± 19.6

89.0 ± 16.0

0.426

FEV1/FVC, %

76.4 ± 11.2

75.1 ± 9.5

0.431

DLco, % predicted

52.7 ± 17.8

60.2 ± 16.2

0.008*

ILD pattern

  

0.270

UIP

29

19

 

Probable UIP

7

10

 

Indeterminate UIP

23

25

 

Alternative diagnosis

16

23

 

Preoperative steroid use, + /−

8/67

7/70

0.745

Preoperative pirfenidone use, + /−

5/70

1/76

0.089

Histology

  

0.220

Adenocarcinoma

32

36

 

Squamous cell carcinoma

32

24

 

Small cell carcinoma

6

5

 

Others

5

12

 

pStage, I/II/IIIA/IIIB

65/5/4/1

54/12/9/2

0.100

Primary tumor size, mm

18 (12–28)

29 (21–39)

 < 0.001*

Operative time, min

139 (77–182)

159 (124–209)

0.006*

Bleeding volume, mL

47 (15–85)

80 (41–140)

 < 0.001*

Incidence of postoperative AE-ILD, n (%)

7 (9.3)

10 (13.0)

0.473

  1. Data are presented as mean ± standard deviation or median (interquartile range) according to their distribution.
  2. AE-ILD acute exacerbation of interstitial lung disease; CEA carcinoembryonic antigen; DLco diffusing capacity for carbon monoxide; FEV1 forced expiratory volume in one second; FVC forced vital capacity; ILD interstitial lung disease; UIP usual interstitial pneumonia; VC vital capacity.
  3. *All P-values were evaluated by comparing patients with and without postoperative AE-ILD using the t-test and Mann–Whitney U tests for normally and non-normally distributed variables and using Pearson’s chi-squared test.
  4. #Sublobar resection group included 41 patients treated with wedge resection and 34 patients treated with segmentectomy.
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