Table 3 Linear mixed-effects model for the change in blood biomarkers.
Variables | Baseline values | Change from the baseline (mean and 95% confidence intervals) | |||
|---|---|---|---|---|---|
6 months | P value | 12 months | P value | ||
BNP (pg/mL) | |||||
HDx | 369.1 (185.0–910.0) | 51.4 (− 267.9 to 370.7) | 0.752 | 127.4 (− 206.1 to 460.9) | 0.454 |
Online-HDF | 287.2 (139.5–907.0) | − 140.7 (− 487.4 to 205.9) | 0.426 | − 111.7 (− 470.0 to 246.7) | 0.541 |
Between-group difference | 192.2 (− 279.2 to 663.5) | 0.424 | 239.1 (− 250.4 to 728.6) | 0.338 | |
NT-proBNP (ng/mL) | |||||
HDx | 3.95 (2.16–6.83) | − 0.31 (− 4.19 to 3.56) | 0.874 | 1.42 (− 2.64 to 5.48) | 0.493 |
Online-HDF | 4.27 (2.19–16.82) | − 3.24 (− 7.40 to 0.92) | 0.127 | − 3.32 (− 7.61 to 0.98) | 0.130 |
Between-group difference | 2.96 (− 2.72 to 8.64) | 0.307 | 4.66 (− 1.25 to 10.57) | 0.122 | |
Troponin-I (ng/mL) | |||||
HDx | 0.06 (0.04–0.09) | 0 (0 to 0.01) | 0.538 | 0 (− 0.01 to 0.01) | 0.550 |
Online-HDF | 0.06 (0.03–0.07) | 0 (− 0.01 to 0.01) | 0.901 | 0 (0 to 0.01) | 0.189 |
Between-group difference | 0 (− 0.03 to 0.01) | 0.224 | 0 (− 0.02 to 0.02) | 0.926 | |
Troponin-T (ng/mL) | |||||
HDx | 0.06 (0.04–0.09) | 0 (− 0.01 to 0) | 0.362 | 0 (− 0.01 to 0.01) | 0.437 |
Online-HDF | 0.06 (0.03–0.07) | − 0.01 (− 0.02 to 0) | 0.130 | − 0.01 (− 0.02 to 0) | 0.139 |
Between-group difference | 0 (− 0.01 to 0.02) | 0.595 | 0 (− 0.01 to 0.02) | 0.526 | |
C-reactive protein (mg/dL) | |||||
HDx | 0.07 (0.04–0.23) | 0.21 (− 0.30 to 0.72) | 0.421 | 0.10 (− 0.43 to 0.62) | 0.722 |
Online-HDF | 0.09 (0.04–0.23) | 0.47 (− 0.08 to 1.01) | 0.095 | − 0.02 (− 0.54 to 0.58) | 0.951 |
Between-group difference | − 0.25 (− 1.00 to 0.50) | 0.511 | 0.08 (− 0.69 to 0.74) | 0.835 | |
Interleukin-6 | |||||
HDx | 9.55 (7.78–11.48) | 4.09 (− 2.28 to 10.47) | 0.208 | 1.85 (− 4.76 to 8.47) | 0.582 |
Online-HDF | 8.40 (7.02–11.94) | 0.55 (− 6.17 to 7.27) | 0.872 | − 1.88 (− 8.77 to 5.00) | 0.592 |
Between-group difference | 3.54 (− 5.72 to 12.80) | 0.453 | 3.74 (− 5.81 to 13.28) | 0.443 | |
