Table 4 Linear mixed-effects model for the change in patient-reported outcomes.

From: Cardiovascular Risk Comparison between Expanded Hemodialysis Using Theranova and Online Hemodiafiltration (CARTOON): A Multicenter Randomized Controlled Trial

Variables

Baseline values

Change from the baseline (mean and 95% confidence intervals)

6 months

P value

12 months

P value

Number of symptoms in DSI

HDx

12 (5–20)

 − 2.0 (− 3.8 to − 0.3)

0.024

 − 1.4 (− 3.3 to 0.5)

0.140

Online-HDF

11 (4–16)

 − 0.5 (− 2.3 to 1.4)

0.634

 − 1.0 (− 2.9 to 1.0)

0.321

Between-group difference

 

 − 1.6 (− 4.2 to 1.0)

0.231

 − 0.4 (− 3.1 to 2.3)

0.765

Overall symptom severity score in DSI

HDx

17 (10–37)

 − 2.1 (–6.1 to 1.9)

0.299

 − 2.7 (− 6.8 to 1.5)

0.208

Online-HDF

18 (6–27)

 − 1.4 (–5.6 to 2.8)

0.517

 − 1.3 (− 5.7 to 3.1)

0.567

Between-group difference

 

 − 0.7 (− 6.5 to 5.1)

0.814

 − 1.4 (− 7.4 to 4.6)

0.651

Degree of fatigue after dialysis

HDx

6 (5–7)

0.1 (− 0.6 to 0.9)

0.702

 − 0.6 (− 1.3 to 0.2)

0.164

Online-HDF

5 (3–6)

 − 0.3 (− 1.1 to 0.5)

0.513

0.1 (− 0.8 to 0.9)

0.880

Between-group difference

 

0.4 (− 0.7 to 1.5)

0.459

 − 0.6 (− 1.8 to 0.5)

0.287

Recovery time after dialysis

HDx

3 (2–3)

0 (− 0.3 to 0.3)

0.975

0 (− 0.3 to 0.4)

0.786

Online-HDF

2 (1–3)

 − 0.1 (− 0.4 to 0.3)

0.730

 − 0.1 (− 0.4 to 0.3)

0.713

Between-group difference

 

0 (− 0.4 to 0.5)

0.912

0.1 (− 0.4 to 0.6)

0.644

  1. DSI dialysis symptom index, HDx expanded hemodialysis, HDF hemodiafiltration.