Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-85471-4, published online 18 March 2021
The original version of this Article contained errors in Figure 1c, where data points in the bar graph plot appeared incorrectly in green colour. As a results, the Figure legend,
“General overview of SGA analysis of btn1 mutants versus ade6 control. (A) Representative images of the SGA plates for control (ade6) and query mutants (btn1Δ, btn1D363G, btn1102–208del), with empty control quadrants shown for ade6 (yellow boxes). (B) Exclusion of small colonies for ade6 control across batches as they represent high variability therefore reducing noise. (C) Principle component biplot of the variance within the SGA data for ade6 control (yellow) and query-mutants btn1Δ (blue), btn1D363G (green), btn1102–208del (red), with experimental batch indicated. (D) Cluster analysis for each strain and all the genes with their normalised colony size difference against ade6 control with batch effects removed. Interactions are coloured in blue for negative interactions (< − 0.5) and yellow for positive interactions (> 0.5). (E) Gene linkage of normalised fitness score for ade6 control and query mutants btn1Δ, btn1D363G, btn1102–208del from one experiment. Vertical dashed line represents ade6 or btn1 gene location, red points represent interaction scores excluded from data since less than 500 kb/500,000 bps from query gene location.”
now reads:
“General overview of SGA analysis of btn1 mutants versus ade6 control. (A) Representative images of the SGA plates for control (ade6) and query mutants (btn1Δ, btn1D363G, btn1102–208del), with empty control quadrants shown for ade6 (yellow boxes). (B) Exclusion of small colonies for ade6 control across batches as they represent high variability therefore reducing noise. (C) Principle component biplot of the variance within the SGA data for ade6 control (yellow) and query-mutants btn1Δ (blue), btn1D363G (orange), btn1102–208del (red), with experimental batch indicated. (D) Cluster analysis for each strain and all the genes with their normalised colony size difference against ade6 control with batch effects removed. Interactions are coloured in blue for negative interactions (< − 0.5) and yellow for positive interactions (> 0.5). (E) Gene linkage of normalised fitness score for ade6 control and query mutants btn1∆, btn1D363G, btn1102–208del from one experiment. Vertical dashed line represents ade6 or btn1 gene location, red points represent interaction scores excluded from data since less than 500 kb/500,000 bps from query gene location.”
The original Figure 1 and accompanying legend appear below.
Furthermore, Table 2 contained errors, where genes for the strains btn1∆, btn1D363G and btn1102–208del in the column ‘Top 5 genes’ appeared incorrectly in bold font. The incorrect and correct values appear below.
Incorrect:
Strains | Interaction type | Top 5 genes |
|---|---|---|
btn1∆ | negative | pfa3, kes1, rid1, efc25, ivn1 |
positive | apt1, blt1, cpp1, rpl2301, alg12 | |
btn1D363G | negative | pfa3, rid1, kes1, efc25, fhn1 |
positive | grx5, cpp1, SPBC1604.03c, apt1, blt1 | |
btn1102-208del | negative | pfa3, nce103, gga22, clg1, kes1 |
positive | SPBC29A3.21, cpp1, gfh1, tfx1, pub3 |
Correct:
Strains | Interaction type | Top 5 genes |
|---|---|---|
btn1∆ | negative | pfa3, kes1, rid1, efc25, ivn1 |
positive | apt1, blt1, cpp1, rpl2301, alg12 | |
btn1D363G | negative | pfa3, rid1, kes1, efc25, fhn1 |
positive | grx5, cpp1, SPBC1604.03c, apt1, blt1 | |
btn1102-208del | negative | pfa3, nce103, gga22, clg1, kes1 |
positive | SPBC29A3.21, cpp1, gfh1, tfx1, pub3 |
General overview of SGA analysis of btn1 mutants versus ade6 control. (A) Representative images of the SGA plates for control (ade6) and query mutants (btn1Δ, btn1D363G, btn1102–208del), with empty control quadrants shown for ade6 (yellow boxes). (B) Exclusion of small colonies for ade6 control across batches as they represent high variability therefore reducing noise. (C) Principle component biplot of the variance within the SGA data for ade6 control (yellow) and query-mutants btn1Δ (blue), btn1D363G (green), btn1102–208del (red), with experimental batch indicated. (D) Cluster analysis for each strain and all the genes with their normalised colony size difference against ade6 control with batch effects removed. Interactions are coloured in blue for negative interactions (< − 0.5) and yellow for positive interactions (> 0.5). (E) Gene linkage of normalised fitness score for ade6 control and query mutants btn1∆, btn1D363G, btn1102–208del from one experiment. Vertical dashed line represents ade6 or btn1 gene location, red points represent interaction scores excluded from data since less than 500 kb/500,000 bps from query gene location.
The original Article has been corrected.
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Minnis, C.J., Townsend, S., Petschnigg, J. et al. Author Correction: Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Sci Rep 11, 14198 (2021). https://doi.org/10.1038/s41598-021-93446-8
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DOI: https://doi.org/10.1038/s41598-021-93446-8
