Table 3 Analysis of mortality concerning PON1 polymorphisms in HD patients showing significant P-values by the log-rank test and Wald test.
Group of HD patients | Type of death | Deaths by inheritance modes | Log-rank test P-value | Wald test P-value | HR (Lower—Upper 95% CI), P-value | Adjusteda HR P-value |
|---|---|---|---|---|---|---|
All smokers, n = 193 | Cardiovascular-related, n = 79 | Recessive (PON1 rs705379) | 0.03 | 0.02 | 1.781 (1.066–2.975), 0.027 | 0.028 |
All cardiac, n = 66 | Recessive (PON1 rs705379) | 0.02 | 0.03 | 1.887 (1.076–3.306), 0.027 | 0.046 | |
Cardiac non-related with CHD, n = 25 | Recessive (PON1 rs705379) | 6e-04 | 0.003 | 7.107 (1.962–25.75), 0.003 | 0.001 | |
Smokers without NIDDM, n = 144 | Cardiovascular-related, n = 52 | Recessive (PON1 rs705379) | 0.008 | 0.01 | 2.390 (1.226–4.660), 0.011 | 0.011 |
All cardiac, n = 45 | Recessive (PON1 rs705379) | 0.02 | 0.02 | 2.414 (1.139–5.134), 0.022 | 0.044 | |
Cardiac non-related with CHD, n = 16 | Recessive (PON1 rs705379) | 0.006 | 0.02 | 6.572 (1.417–30.47), 0.016 | 0.009 | |
Smokers without NIDDM, n = 148 | Cardiovascular-related, n = 54 | Dominant (PON1 rs854560) | 0.04 | 0.04 | 0.446 (0.203–0.981), 0.045 | 0.008 |
Smokers with NIDDM, n = 49 | All cardiac, n = 20 | Dominant (PON1 rs662) | 0.03 | 0.04 | 3.410 (1.056–11.02), 0.040 | 0.005 |
All non-smokers, n = 624 | Cardiovascular-related, n = 226 | Dominant (PON1 rs662) | 0.02 | 0.02 | 1.372 (1.048–1.797), 0.022 | 0.020 |
Non-smokers without NIDDM, n = 470 | Cardiovascular-related, n = 145 | Dominant (PON1 rs662) | 0.01 | 0.01 | 1.531 (1.088–2.154), 0.015 | 0.018 |
All non-smokers, n = 645 | Cardiac non-related with CHD, n = 75 | Recessive (PON1 rs854560) | 0.04 | 0.04 | 0.435 (0.194–0.978), 0.044 | 0.079 |
Non-smokers with NIDDM, n = 156 | Cardiac related with CHD, n = 40 | Dominant (PON1 rs705379) | 0.02 | 0.02 | 2.511 (1.134–5.558), 0.023 | 0.020 |
