Table 3 Topology table for up and down regulated genes.

From: Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis

Regulation

Node

Degree

Betweenness

Stress

Closeness

Up

MYC

769

0.24506

1.04E + 08

0.402932

Up

EGFR

469

0.138032

61,812,344

0.381322

Up

LNX1

301

0.098028

35,639,540

0.344753

Up

YBX1

242

0.052423

15,440,248

0.370488

Up

HSP90AA1

198

0.042012

18,645,766

0.349323

Up

RNPS1

148

0.029398

16,186,898

0.324119

Up

SGTA

139

0.039126

11,319,544

0.315439

Up

TNFRSF1A

116

0.016842

8,191,032

0.328598

Up

SQSTM1

112

0.025913

6,213,766

0.344335

Up

MAST3

105

0.022

12,287,012

0.305669

Up

POU6F2

99

0.028224

4,939,174

0.317338

Up

STUB1

95

0.01869

5,557,470

0.333856

Up

FKBP5

94

0.015263

3,991,284

0.329764

Up

PRMT6

82

0.023047

4,016,020

0.301486

Up

MAPK3

78

0.01798

4,710,364

0.312259

Up

SMAD1

77

0.014129

5,216,492

0.309237

Up

TFAP2C

77

0.020062

3,309,460

0.333573

Up

NCL

73

0.015947

5,344,646

0.374917

Up

ETS1

69

0.014065

3,895,426

0.310987

Up

MEX3C

68

0.003769

2,594,352

0.310439

Up

ACD

66

0.014094

3,525,238

0.307138

Up

NFKBIA

66

0.008138

4,939,524

0.310854

Up

GAB1

61

0.005759

2,357,788

0.296365

Up

ZNF581

58

0.008074

2,392,056

0.303509

Up

PRKACA

58

0.012141

2,683,394

0.312833

Up

KRT13

56

0.009539

2,356,276

0.31577

Up

SF3A1

54

0.005297

3,631,052

0.304231

Up

STAT1

54

0.010129

1,749,810

0.330531

Up

ATF7IP

54

0.011319

2,610,676

0.297746

Up

FOXK1

52

0.010322

2,431,366

0.309968

Up

KRT16

52

0.009137

2,768,286

0.302646

Up

RPS6

50

0.005709

1,809,230

0.323503

Up

IFIT3

48

0.004333

1,419,676

0.307396

Up

UBE2E2

48

0.009384

2,778,786

0.289714

Up

PKN1

47

0.007325

2,119,206

0.29714

Up

ARL6IP1

46

0.011853

5,167,578

0.284047

Up

UTP14A

45

0.00788

1,716,012

0.322239

Up

PRPF8

44

0.006824

1,731,078

0.329977

Up

GADD45G

44

0.007648

1,727,574

0.29879

Up

ATP13A2

43

0.011364

3,235,048

0.28605

Up

HRAS

42

0.006113

1,934,688

0.306916

Up

DCC

42

0.005613

2,081,812

0.292265

Up

SUN2

42

0.004561

2,137,880

0.299806

Up

DYSF

41

0.007116

2,286,238

0.293962

Up

NCSTN

40

0.007729

5,776,106

0.274308

Up

RPL8

37

0.004561

1,421,422

0.324922

Up

BACH2

37

0.008838

2,796,552

0.273369

Up

PIK3CA

37

0.005768

1,280,756

0.304576

Up

PTBP1

36

0.003339

1,190,818

0.333507

Up

FKBP8

35

0.00586

1,371,274

0.3223

Up

NES

35

0.007013

1,126,640

0.295338

Up

KRT6A

34

0.005784

1,381,296

0.320281

Up

NUP205

33

0.005495

1,090,580

0.323442

Up

FOXP1

33

0.006278

1,144,548

0.31992

Up

INSR

33

0.003132

1,562,024

0.279757

Up

BCAP31

32

0.00482

1,838,970

0.292131

Up

BTF3

31

0.00454

1,476,600

0.290636

Up

RPL18A

31

0.002498

754,566

0.318306

Up

KIAA0408

30

0.00425

1,221,042

0.302575

Up

USP1

30

0.004591

2,441,058

0.280879

Up

EIF3B

29

0.003846

916,674

0.315848

Up

HSPA2

28

0.002862

684,442

0.313947

Up

RPS28

28

0.002873

1,278,818

0.301718

Up

SOS1

28

0.002513

879,664

0.284205

Up

ERRFI1

26

0.002199

611,152

0.311214

Up

LCE3E

26

0.001327

524,110

0.25448

Up

GSK3A

26

0.004252

1,655,588

0.292867

Up

NAT10

26

0.001696

666,842

0.325191

Up

LIG3

26

0.00228

725,644

0.294691

Up

RPL18

25

9.73E−04

477,540

0.322646

Up

SLC1A5

25

0.004674

807,018

0.306677

Up

EIF4B

25

0.00188

620,280

0.295594

Up

NEDD9

24

0.003127

549,922

0.289271

Up

CASC3

23

0.002491

601,190

0.302503

Up

FOSL2

23

0.003682

831,006

0.310911

Up

SMURF1

22

0.002704

664,080

0.284142

Up

PLOD3

22

0.003554

1,082,282

0.335808

Up

TCOF1

22

0.00218

501,286

0.314295

Up

ZNF326

22

0.001349

640,724

0.29001

Up

SP4

22

0.003993

853,624

0.26749

Up

EGR1

21

0.002422

466,912

0.302056

Up

MAGEA2

21

0.004402

1,011,862

0.293759

Up

CREB3L1

21

0.006704

4,786,040

0.227129

Up

WASF1

20

0.003044

1,067,564

0.274868

Up

IRS1

20

0.001568

411,892

0.309837

Up

CRTC3

20

0.002135

967,284

0.279558

Up

FBP2

20

9.48E−04

423,694

0.288846

Up

MED25

20

0.001218

294,794

0.275609

Up

LCE3D

20

4.82E−04

304,904

0.263329

Up

DEAF1

19

0.002531

618,844

0.3017

Up

PDK3

19

0.003011

604,606

0.307526

Up

RPL19

19

6.37E−04

392,064

0.319241

Up

ABCA1

19

0.004473

1,062,228

0.298441

Up

SAE1

19

0.003167

702,666

0.299157

Up

MAL

19

0.004533

1,470,896

0.264227

Up

RAB4A

19

0.003857

747,204

0.292398

Up

RALB

19

0.001738

1,634,506

0.255536

Up

TRAPPC3

19

0.005096

1,890,182

0.252046

Up

DPP4

19

0.00527

1,619,646

0.234023

Up

PRKCSH

18

0.002123

375,070

0.316043

Up

RBM22

18

0.002051

950,490

0.283386

Up

CAMSAP3

18

0.002085

1,031,300

0.274014

Up

AK1

18

0.002632

1,174,620

0.257986

Up

TTI1

17

0.001947

994,560

0.275505

Up

RUNX1T1

17

0.002454

1,455,104

0.275046

Up

RPS15

16

0.00225

468,552

0.316395

Up

NR0B2

16

0.002709

597,146

0.313581

Up

POLR1D

16

0.001752

656,232

0.282369

Up

FAM83B

16

8.49E−04

301,500

0.277314

Up

PBX1

16

0.001944

703,560

0.258718

Up

TCF7L2

15

0.001345

373,312

0.28326

Up

BCOR

15

0.002336

806,128

0.273164

Up

ID3

15

0.002818

819,716

0.269962

Up

SLC35E1

15

0.003323

1,409,720

0.24654

Up

TPI1

14

0.002071

457,522

0.314391

Up

SIAH2

14

0.001994

845,214

0.269677

Up

TNKS

14

0.002475

650,184

0.251959

Up

RBM23

14

2.87E−04

166,572

0.276758

Up

HEYL

14

0.002211

402,860

0.280864

Up

MRPL37

2

1.61E−04

51,382

0.28108

Up

GID8

2

4.01E−05

6218

0.246921

Up

DIP2B

2

0

0

0.291299

Up

SH3RF1

2

2.53E−04

99,400

0.287919

Up

ZFP36L1

2

9.45E−05

13,940

0.255792

Up

GCG

2

1.27E−04

41,870

0.209131

Up

YIPF3

2

7.28E−05

18,416

0.211048

Up

FGB

1

0

0

0.254404

Up

FAM20C

1

0

0

0.254404

Up

GLI3

1

0

0

0.236207

Up

NXN

1

0

0

0.215614

Up

PHLDA1

1

0

0

0.276071

Up

SPRR1A

1

0

0

0.276071

Up

DNAJC4

1

0

0

0.276071

Up

MRPL49

1

0

0

0.270347

Up

COL6A3

1

0

0

0.22719

Up

MZT2B

1

0

0

0.287223

Up

ZFHX3

1

0

0

0.287223

Up

SNX19

1

0

0

0.287223

Up

KLF10

1

0

0

0.287223

Up

ST6GALNAC6

1

0

0

0.287223

Up

RPRD2

1

0

0

0.287223

Up

ETV6

1

0

0

0.287223

Up

SYVN1

1

0

0

0.273764

Up

SPRR2D

1

0

0

0.229084

Up

FGF21

1

0

0

0.239809

Up

TMEM174

1

0

0

0.239809

Up

CYGB

1

0

0

0.222435

Up

CRNN

1

0

0

0.256151

Up

PLCE1

1

0

0

0.258901

Up

SFTPD

1

0

0

0.201125

Up

TRIM24

1

0

0

0.273179

Up

APOD

1

0

0

0.273179

Up

THRB

1

0

0

0.21607

Up

IKZF4

1

0

0

0.23715

Up

SPRR3

1

0

0

0.23715

Up

CNTNAP4

1

0

0

0.23412

Up

ZNRF1

1

0

0

0.224644

Up

ATXN7L1

1

0

0

0.211048

Up

FLG

1

0

0

0.219296

Up

MT2A

1

0

0

0.250147

Up

SHISA5

1

0

0

0.250147

Up

RWDD2B

1

0

0

0.230063

Up

OAS1

1

0

0

0.231658

Up

TMED5

1

0

0

0.231658

Up

NR1D2

1

0

0

0.231658

Up

GPATCH4

1

0

0

0.228011

Up

KLF11

1

0

0

0.217829

Up

ZFP36

1

0

0

0.239696

Up

MTMR3

1

0

0

0.239696

Up

FOXN3

1

0

0

0.239696

Up

PGAP2

1

0

0

0.221817

Up

ELK1

1

0

0

0.237967

Up

DUSP1

1

0

0

0.237967

Up

IL6ST

1

0

0

0.248433

Up

SNX12

1

0

0

0.221222

Up

LSM11

1

0

0

0.237183

Up

MED13L

1

0

0

0.232501

Down

ESR1

448

0.115717

68,567,806

0.375827

Down

FN1

445

0.130416

47,618,446

0.393806

Down

TK1

155

0.044276

10,622,930

0.341187

Down

ANLN

102

0.019831

5,950,428

0.327945

Down

SMAD9

99

0.023512

10,495,428

0.31337

Down

NEDD8

94

0.013216

4,708,022

0.323626

Down

TTN

88

0.021791

4,877,390

0.354606

Down

CDK1

76

0.019122

4,123,802

0.343387

Down

KRTAP4-2

73

0.019925

3,654,538

0.300106

Down

MED10

65

0.012717

3,973,710

0.302915

Down

EXOSC8

61

0.015702

2,371,472

0.315244

Down

NEK6

61

0.009473

2,973,110

0.31289

Down

OIP5

60

0.013758

3,810,166

0.30688

Down

PSMA6

57

0.012284

2,937,164

0.324778

Down

BUB1B

54

0.010813

5,323,030

0.298111

Down

FOXM1

43

0.007242

2,131,654

0.300317

Down

RPL31

35

0.003717

1,156,016

0.323013

Down

EEF1A2

33

0.002074

927,396

0.307212

Down

JMJD6

31

0.006976

4,154,054

0.261751

Down

VASP

30

0.005691

1,017,020

0.316768

Down

MAP3K8

30

0.001715

773,154

0.310458

Down

UCHL1

28

0.003224

905,164

0.308808

Down

TOP2A

28

0.0032

1,042,178

0.328788

Down

MYH11

28

0.003406

1,173,838

0.305103

Down

RASSF1

27

0.004112

1,253,252

0.299175

Down

KRTAP3-2

27

0.004532

1,398,432

0.265421

Down

TXNDC9

26

0.004126

1,143,166

0.278477

Down

ACTC1

24

0.004063

1,053,202

0.329594

Down

SPC24

23

0.002762

801,496

0.268982

Down

SH3BP2

21

0.001863

813,564

0.277887

Down

IGF2BP3

20

0.001318

388,432

0.332401

Down

KIF20A

20

0.004794

850,452

0.262706

Down

SFRP4

20

0.001565

724,830

0.277404

Down

KIF20B

18

0.003465

529,620

0.306935

Down

RASD1

18

0.001969

611,526

0.282869

Down

NEFM

18

0.002405

500,776

0.29515

Down

RADIL

18

0.001925

718,708

0.28187

Down

LCE1F

18

5.31E−04

1,078,996

0.215551

Down

LUC7L

17

0.001779

331,232

0.297175

Down

LYZ

17

0.002823

462,382

0.311441

Down

PFKFB2

17

0.002624

984,686

0.285029

Down

ACTBL2

17

5.95E−04

248,094

0.310647

Down

FCHO1

17

0.002083

725,112

0.267588

Down

KIF18A

17

0.002914

1,632,588

0.264802

Down

SAMHD1

16

0.002408

964,652

0.269962

Down

LAT

15

0.002067

607,316

0.301593

Down

PBK

15

0.002668

669,380

0.294912

Down

TPX2

15

9.04E−04

407,858

0.293506

Down

RRM2

15

0.002347

419,566

0.272147

Down

LAMB3

15

0.002279

1,460,718

0.265531

Down

ALOX5

15

0.003126

496,364

0.267099

Down

TPM2

15

4.76E−04

162,954

0.290092

Down

IP6K3

14

0.001497

346,042

0.275387

Down

VAV3

14

0.001429

470,180

0.297573

Down

NDUFA8

13

0.00167

479,156

0.290455

Down

BIRC8

13

0.002152

927,372

0.24679

Down

DLG2

13

0.002105

767,688

0.273896

Down

MYCN

12

1.11E−04

41,976

0.304939

Down

PRAM1

12

0.001039

343,780

0.260883

Down

PCDH7

12

0.001704

788,890

0.266375

Down

EDARADD

11

0.001215

325,252

0.268544

Down

GREB1

11

9.15E−04

206,196

0.268968

Down

ZNF622

11

8.30E−04

730,808

0.269663

Down

RXRG

11

0.002054

800,986

0.250012

Down

GLP1R

11

3.87E−04

306,068

0.257778

Down

TTC8

11

0.003532

958,578

0.227362

Down

SERPINA3

10

0.002011

543,412

0.243151

Down

CDK15

10

2.37E−04

85,694

0.294623

Down

HLA-DQA1

10

0.001488

682,934

0.249878

Down

HSD17B3

10

1.13E−04

75,794

0.26087

Down

TSHZ3

10

0.001111

304,690

0.256253

Down

MAP1A

9

8.61E−04

207,068

0.312393

Down

CSNK1G1

9

0.001614

637,430

0.248529

Down

GTF2H2C

9

0.001734

341,202

0.245876

Down

PDLIM3

9

0.001957

559,870

0.239831

Down

WDR3

9

6.45E−04

234,640

0.274455

Down

TNFAIP8

9

9.44E−04

850,962

0.230957

Down

ADAMTS10

8

9.45E−04

260,474

0.258443

Down

ABCB1

8

9.74E−04

146,904

0.3

Down

QRICH2

8

0.001291

295,070

0.261336

Down

INS

8

4.75E−04

194,074

0.248216

Down

COMP

8

0.001207

326,670

0.231995

Down

SHCBP1

7

4.46E−04

233,846

0.256678

Down

DLGAP5

7

1.46E−04

74,806

0.290108

Down

ARHGAP9

7

3.62E−04

66,924

0.28522

Down

KCNH1

7

3.41E−04

213,892

0.253094

Down

KLHL1

6

1.15E−04

30,788

0.283638

Down

LCN2

6

4.47E−04

83,350

0.256575

Down

TYMS

6

4.58E−04

134,624

0.25317

Down

CDKN1C

6

4.20E−04

155,814

0.26589

Down

DMBT1

6

0.001176

361,022

0.251748

Down

SULT1C2

6

4.34E−04

98,520

0.244289

Down

IL10

6

8.05E−04

231,670

0.245675

Down

SAMD3

6

6.69E−04

135,970

0.268713

Down

NCKAP5

6

4.03E−05

22,814

0.2639

Down

CNN1

6

2.65E−04

64,314

0.23624

Down

PREX1

6

8.35E−04

387,030

0.254975

Down

CTNNA2

5

5.71E−04

182,504

0.281204

Down

POU5F1

5

7.40E−04

107,680

0.274839

Down

POSTN

5

5.96E−04

207,158

0.228766

Down

CSF2RA

5

8.10E−04

258,390

0.252907

Down

MATN3

5

1.69E−04

28,890

0.235848

Down

ASB9

5

5.76E−04

238,362

0.238055

Down

KRTAP5-1

5

0.001174

179,682

0.190051

Down

IL5RA

5

0.001176

281,872

0.257441

Down

KANK4

5

7.94E−04

141,232

0.240633

Down

ASB16

5

2.41E−05

16,592

0.266028

Down

KIF4A

5

4.60E−05

13,994

0.259374

Down

ROBO1

5

4.93E−04

116,624

0.246421

Down

TNFRSF11A

4

4.04E−04

116,804

0.251934

Down

KRTAP3-1

4

2.89E−05

20,452

0.252494

Down

UBXN10

4

5.63E−04

69,202

0.248047

Down

GLG1

4

4.17E−04

62,018

0.265572

Down

LOXL1

4

4.78E−04

74,588

0.250404

Down

COMMD7

4

4.03E−04

180,366

0.233127

Down

SELPLG

4

8.09E−04

244,340

0.221136

Down

YIPF4

4

4.79E−05

15,522

0.197986

Down

TMEM108

4

2.77E−05

10,972

0.243081

Down

KRTAP13-3

3

3.50E−07

422

0.210396

Down

LRRC7

3

7.82E−04

166,682

0.180159

Down

GPX2

2

0

0

0.299578

Down

CDH23

1

0

0

0.215614

Down

ISX

1

0

0

0.240905

Down

NPTX2

1

0

0

0.287223

Down

KCNG3

1

0

0

0.287223

Down

SMIM5

1

0

0

0.239809

Down

TFF3

1

0

0

0.239809

Down

FAM111B

1

0

0

0.222435

Down

CDKN3

1

0

0

0.255626

Down

IFI27L2

1

0

0

0.250147

Down

NTN1

1

0

0

0.226175

Down

AGAP2

1

0

0

0.218611

Down

PIR

1

0

0

0.238611

Down

RNASE2

1

0

0

0.215016

Down

ADCYAP1

1

0

0

0.189649

Down

HADH

1

0

0

0.248433

Down

NDRG4

1

0

0

0.221222

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