Table 3 Clinical characteristics of patients in the presence or absence of anti-Ro52/tripartite motif-containing 21 antibodies (anti-Ro52).

Age (years)

69.5 [63–75]

67.5 [63–74]

70 [63–75]

0.35

Male, n (%)

193 (67)

11 (55)

182 (68)

0.17

Smoking (pack-years)

22 [0–48]

19 [0–42]

23 [0–49]

0.79

Fulfilled IPAF criteria, n (%)

55 (19)

10 (50)

45 (17)

0.001

Clinical domain, n (%)

26 (9)

4 (20)

22 (8)

0.09

Serological domain, n (%)

86 (30)

15 (75)

71 (26)

 < 0.001

Morphological domain, n (%)

127 (44)

8 (40)

119 (44)

0.44

Respiratory symptoms

Cough^#, n (%)

164 (59)

12 (63)

152 (59)

0.47

Sputum^¶, n (%)

62 (23)

2 (11)

60 (24)

0.15

Dyspnea⁺, n (%)

177 (67)

15 (83)

162 (66)

0.10

Clinical symptoms related to SARD

Mechanic's hands^§, n (%)

3 (1)

1 (5)

2 (1)

0.20

Distal digital tip ulceration^ƒ, n (%)

2 (1)

0 (0)

2 (1)

0.87

Inflammatory arthritis^ƒ, n (%)

15 (5)

1 (5)

14 (5)

0.72

Palmar telangiectasia^§, n (%)

0 (0)

0 (0)

0 (0)

–

Raynaud's phenomenon^§, n (%)

7 (2)

3 (15)

4 (2)

0.009

Unexplained digital edema^§, n (%)

2 (1)

0 (0)

2 (1)

0.864

Gottron's sign^ƒ, n (%)

0 (0)

0 (0)

0 (0)

–

Muscle weakness^##, n (%)

2 (1)

0 (0)

2 (1)

0.87

Weight loss^¶¶, n (%)

15 (5)

1 (5)

14 (5)

0.71

Dry mouth or dry eye^ƒ, n (%)

7 (2)

0 (0)

7 (3)

0.60

Dysphagia^ƒ, n (%)

6 (2)

0 (0)

6 (2)

0.65

Gastroesophageal reflux disease⁺⁺, n (%)

23 (36)

1 (25)

22 (37)

0.55