Table 4 Tests and findings of patients with/without anti-Ro52/tripartite motif-containing 21 antibodies (anti-Ro52).

Subjects	All	Anti-Ro52 positive	Anti-Ro52 negative	P value
Subjects	n = 288	n = 20	n = 268	P value
Laboratory findings
CRP (mg/dL)^#	0.48 [0.12–2.66]	0.30 [0.17–1.73]	0.49 [0.12–2.7]	0.93
LDH (IU/L)^¶	225 [192–288]	226 [187–291]	225 [193–288]	0.54
CK (IU/L)⁺	74 [51–114]	77 [55–126]	73 [51–113]	0.42
KL-6 (U/mL)^§	878 [491–1554]	1258 [807–2604]	858 [476–1462]	0.01
SP-A (ng/mL)^ƒ	73 [49–107]	87 [72–109]	72 [47–107]	0.36
SP-D (ng/mL)^##	220 [118–340]	180 [121–335]	220 [118–341]	0.91
Pulmonary function tests^¶¶
VC (% predicted)	79 [64–94]	76 [63–85]	80 [64–95]	0.36
FEV₁/FEV (% predicted)	82 [76–88]	81 [78–86]	82 [76–88]	0.78
DL_CO (% predicted)	59 [42–74]	63 [41–68]	58 [42–74]	0.76
Bronchoalveolar lavage fluid⁺⁺
TCC (× 10⁵/mL)	2.8 [1.8–4.5]	2.9 [1.7–4.9]	2.8 [1.8–4.5]	0.84
Macrophages (%)	69.1 [50.3–80.6]	76.9 [62.0–78.9]	68.7 [50.0–80.7]	0.43
Lymphocytes (%)	12.7 [6.5–28.1]	10.8 [6.2–18.2]	12.8 [6.5–18.1]	0.39
Neutrophils (%)	6.3 [2.9–13.5]	4.5 [2.8–10.3]	6.6 [2.9–13.6]	0.64
Eosinophils (%)	3.1 [1.1–6.2]	3.3 [1.3–4.3]	3.1 [1.1–6.3]	0.80
CD4/CD8	1.7 [0.8–2.7]	1.4 [0.4–3.5]	1.7 [0.8–2.7]	0.60

Data presented as median [interquartile range] or frequencies (%).
n = 288, unless otherwise stated; ^#n = 279; ^¶n = 278; ⁺n = 229; ^§n = 260; ^ƒn = 137; ^##n = 210; ^¶¶n = 209; ⁺⁺n = 218.
Ro52: Ro52/tripartite motif-containing 21; CRP: C-reactive protein; LDH: lactate dehydrogenase; CK: creatine kinase; KL-6: Krebs von den Lungen-6; SP-A: surfactant protein-A; SP-D: surfactant protein-D; VC: vital capacity; FEV₁: forced expiratory volume in one second; DL_CO: diffusing capacity of the lung for carbon monoxide; TCC: total cell counts; CD: cluster of differentiation.
P value: anti-Ro52 positive vs. anti-Ro52 negative.

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