Table 3 MR Estimates for the effects of physical activity on AD risk in IGAP datasets.

From: Using a two-sample mendelian randomization analysis to explore the relationship between physical activity and Alzheimer’s disease

Exposure

Outcome

Outcome units

Method

SNPs

P

OR

95%CI

Q

Q_df

Q p-val

I2

MR Egger

MR-PRESSO

Intercept

95%CI

Intercept pval

Global test P

SNPs

OR

P

Overall activity

Alzhemier's disease

Log odds ratio

MR Egger

3

0.2207

0.00

(0.00,0.14)

0.67

1

0.412

0.00

0.19

(0.05,0.33)

0.234

0.004

2

1.02 (0.16, 6.58)

0.996

IVW

3

0.4805

0.62

(0.17,2.32)

7.43

2

0.024

0.73

       

IVW (mre)

3

0.4805

0.62

(0.17,2.32)

           

Weighted median

3

0.0362

0.35

(0.13,0.92)

           

Sedentary behavior

Alzheimer’s disease

Log odds ratio

MR Egger

3

0.8147

1.40

(0.06,41.95)

0.01

1

0.922

0.00

− 0.01

(− 0.10,0.09)

0.916

0.185

   

IVW

3

0.4131

1.33

(0.68,2.60)

0.00

2

0.987

0.00

       

IVW (mre)

3

0.0000

1.33

(1.23,1.43)

           

Weighted median

3

0.5103

1.30

(0.60,2.80)

           

Walking

Alzheimer’s disease

Log odds ratio

IVW

2

0.0039

0.30

(0.13,0.68)

0.68

1

0.411

0.00

NA

NA

NA

NA

   

IVW (mre)

2

0.0004

0.30

(0.15,0.59)

           

Moderate-intensity activity

Alzheimer’s disease

Log odds ratio

MR Egger

25

0.8918

1.06

(0.49,2.28)

26.06

23

0.298

0.12

− 0.01

(− 0.03,0.01)

0.450

0.165

   

IVW

25

0.1371

0.80

(0.59,1.07)

           

IVW (mre)

25

0.1371

0.80

(0.59,2.07)

26.73

24

0.317

0.10

       

Weighted median

25

0.9210

0.98

(0.65,1.46)

           
  1. SNPs, single nucleotide polymorphisms; CI, confidence interval; OR, odds ratio; Q, Cochran Q statistics; IVW, inverse variance weighted; WM, weighted median; MR-Egger, Mendelian randomization-Egger; MR-PRESSO,MR pleiotropy residual sum and outlier.
  2. Phet: P-values of Cochran’s Q test for heterogeneity were shown.
  3. Pint: P-values of MR-Egger regression test on the intercept.
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