Table 3 Results of the haplotype based association analyses.

From: Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population

Locus

Length (kb)

Haplotype

F_A

F_U

χ2

DF

P

OR [95%CI]a

SNPs

H1

1.23

OMNIBUS

–

–

65.60

2

5.69 × 10–15

 

rs1108842|rs11177

CA

0.49

0.44

14.23

1

0.0002

Ref

rs1108842|rs11177

CG

0.01

0.04

59.13

1

1.48 × 10–14

0.82 [0.74–0.90]

rs1108842|rs11177

AG

0.50

0.52

1.19

1

0.2763

 

rs1108842|rs11177

H2

0.74

OMNIBUS

–

–

2.47

2

0.2914

 

rs13076193|rs6762813

AT

0.46

0.46

0.01

1

0.9135

Ref

rs13076193|rs6762813

AC

0.04

0.03

2.44

1

0.1186

1.00 [0.90–1.11]

rs13076193|rs6762813

CC

0.50

0.51

0.23

1

0.6342

 

rs13076193|rs6762813

  1. F_A, haplotype frequency in patients with hand OA; F_U, haplotype frequency in controls; DF, degree of freedom.
  2. aFor H1, the ORs were calculated for CG + AG versus CA. For H2, the ORs were calculated for AC + CC versus AT.
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