Table 3 Univariate Cox regression analysis and multivariate regression analyses of OS in the TMA cohort.
From: Development of a prognostic model for anoikis and identifies hub genes in hepatocellular carcinoma
A. BIRC5 and SKP2 overall survival (OS) univariate analysis | |||||
|---|---|---|---|---|---|
Characteristics | Total (N) | Univariate analysis | |||
Hazard ratio (95% CI) | P value | ||||
Gender (female vs. male) | 88 | 0.465 (0.139–1.560) | 0.215 | ||
Age (> 60 vs. ≤ 60) | 88 | 1.344 (0.602–3.000) | 0.471 | ||
T stage (T3 and T4 vs. T1 and T2) | 88 | 6.465 (2.841–14.713) | < 0.001 | ||
N stage (N1 vs N0) | 88 | 1.788 (0.241–13.260) | 0.570 | ||
Pathological stage (stage III and IV vs. stage I and II) | 88 | 6.465 (2.841–14.713) | < 0.001 | ||
Histologic grade (G3 and G4 vs. G1 and G2) | 88 | 2.783 (1.228–6.106) | 0.014 | ||
AFP(IU/ml) (> 6.7 vs. ≤ 6.7) | 88 | 1.896 (0.753–4.778) | 0.175 | ||
Vascular invasion (yes vs. no) | 88 | 1.960 (0.812–4.729) | 0.135 | ||
BIRC5 (high expression vs. low expression) | 88 | 7.636 (1.031–56.572) | 0.047 | ||
SKP2 (high expression vs. low expression) | 88 | 7.481 (1.010–55.413) | 0.049 | ||
B. BIRC5 and SKP2 overall survival (OS) multivariate analysis | |||||
|---|---|---|---|---|---|
Characteristics | Total (N) | BIRC5 Multivariate analysis | SKP2 Multivariate analysis | ||
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
Pathological stage (stage III and IV vs. stage I and II) | 88 | 6.018 (2.169–16.695) | 0.001 | 6.088 (2.180–16.999) | 0.001 |
Histologic grade G3 and G4 vs. G1 and G2) | 88 | 2.521 (1.085–5.857) | 0.032 | 2.597 (1.100–6.134) | 0.029 |
AFP(IU/ml) (> 6.7 vs. ≤ 6.7) | 88 | 0.931 (0.342–2.535) | 0.889 | 1.344 (0.495–3.650) | 0.562 |
Vascular invasion (yes vs. no) | 88 | 0.835 (0.288–2.415) | 0.793 | 0.727 (0.241–2.192) | 0.571 |
BIRC5/SKP2 (high expression vs. low expression) | 88 | 4.012 (0.508–31.676) | 0.188 | 5.998 (0.788–45.668) | 0.084 |
