Table 1 List of salivary proteins specific for ruptured ectopic pregnancy women (REP), identified by LC–MS/MS.
From: Ectopic pregnancy: search for biomarker in salivary proteome
S.no. | UniprotACa | Protein descriptionb | Gene nameb | AAsb | MWb | pIb | #Peptides | #Unique peptides |
|---|---|---|---|---|---|---|---|---|
1. | P0C0L5 | Complement C4-B | C4B | 1744 | 192,751 | 6.89 | 11 | 11 |
2. | P07195 | L-lactate dehydrogenase B chain | LDHB | 334 | 36,638 | 5.71 | 5 | 4 |
3. | P40926 | Malate dehydrogenase, mitochondrial | MDH2 | 338 | 35,503 | 8.92 | 4 | 4 |
4. | O00391 | Sulfhydryl oxidase 1 | QSOX1 | 747 | 82,578 | 9.13 | 3 | 3 |
5. | P09960 | Leukotriene A-4 hydrolase | LTA4H | 611 | 69,285 | 5.8 | 3 | 3 |
6. | P22735 | Protein-glutamine gamma-glutamyltransferase K | TGM1 | 817 | 89,787 | 5.68 | 3 | 3 |
7. | P22894 | Neutrophil collagenase | MMP8 | 467 | 53,412 | 6.38 | 3 | 3 |
8. | Q9UKR3 | Kallikrein-13 | KLK13 | 277 | 30,570 | 8.78 | 3 | 3 |
9. | P05120* | Plasminogen activator inhibitor 2 | SERPINB2 | 415 | 46,596 | 5.46 | 2 | 2 |
10. | P15309 | Prostatic acid phosphatase | ACPP | 386 | 44,566 | 5.83 | 2 | 2 |
11. | P27695 | DNA- (apurinic or apyrimidinic site) lyase | APEX1 | 318 | 35,555 | 8.33 | 2 | 2 |
12. | P36222 | Chitinase-3-like protein 1 | CHI3L1 | 383 | 42,625 | 8.69 | 2 | 2 |
13. | P52907 | F-actin-capping protein subunit alpha-1 | CAPZA1 | 286 | 32,923 | 5.45 | 2 | 2 |
14. | P61916 | NPC intracellular cholesterol transporter 2 | NPC2 | 151 | 16,570 | 7.57 | 2 | 2 |
15. | Q15782 | Chitinase-3-like protein 2 | CHI3L2 | 390 | 43,501 | 7.11 | 2 | 2 |
16. | Q6P4A8 | Phospholipase B-like 1 | PLBD1 | 553 | 63,255 | 9.11 | 2 | 2 |
17. | Q9NP55 | BPI fold-containing family A member 1 | BPIFA1 | 256 | 26,713 | 5.42 | 2 | 2 |
18. | P15311 | Ezrin | EZR | 586 | 69,413 | 5.94 | 3 | 1 |
19. | A0A087WSY6 | Immunoglobulin kappa variable 3D-15 | IGKV3D-15 | 115 | 12,534 | 5.14 | 2 | 1 |
20. | A0A0B4J1X8 | Immunoglobulin heavy variable 3–43 | IGHV3-43 | 118 | 13,077 | 5.28 | 2 | 1 |
21. | A0A0C4DH29 | Immunoglobulin heavy variable 1–3 | IGHV1-3 | 117 | 13,008 | 9.59 | 2 | 1 |
22. | P01602 | Immunoglobulin kappa variable 1–5 | IGKV1-5 | 117 | 12,782 | 8.49 | 2 | 1 |
23. | P01624 | Immunoglobulin kappa variable 3–15 | IGKV3-15 | 115 | 12,496 | 5.14 | 2 | 1 |
24. | P01743 | Immunoglobulin heavy variable 1–46 | IGHV1-46 | 117 | 12,933 | 9.1 | 2 | 1 |
25. | P01766 | Immunoglobulin heavy variable 3–13 | IGHV3-13 | 116 | 12,506 | 6.54 | 2 | 1 |
26. | P13797 | Plastin-3 | PLS3 | 630 | 70,811 | 5.41 | 2 | 1 |
27. | P13929 | Beta-enolase | ENO3 | 434 | 46,987 | 7.58 | 2 | 1 |
28. | P19652 | Alpha-1-acid glycoprotein 2 | ORM2 | 201 | 23,603 | 5.03 | 2 | 1 |
29. | P23083 | Immunoglobulin heavy variable 1–2 | IGHV1OR15-1 | 117 | 13,085 | 9.23 | 2 | 1 |
30. | Q13162 | Peroxiredoxin-4 | PRDX4 | 271 | 30,540 | 5.86 | 2 | 1 |
31. | Q14651 | Plastin-1 | PLS1 | 629 | 70,253 | 5.28 | 2 | 1 |
32. | A0A075B6I4 | Immunoglobulin lambda variable 10–54 | IGLV10-54 | 117 | 12,395 | 7.85 | 1 | 1 |
33. | A0A075B6S5 | Immunoglobulin kappa variable 1–27 | IGKV1-27 | 117 | 12,712 | 8.5 | 1 | 1 |
34. | A0A0A0MS14 | Immunoglobulin heavy variable 1–45 | IGHV1-45 | 117 | 13,508 | 9.2 | 1 | 1 |
35. | A0A0B4J2D9 | Immunoglobulin kappa variable 1D-13 | IGKV1D-13 | 117 | 12,569 | 7.68 | 1 | 1 |
36. | O43307 | Rho guanine nucleotide exchange factor 9 | ARHGEF9 | 516 | 60,982 | 5.47 | 1 | 1 |
37. | O43451 | Maltase-glucoamylase, intestinal | MGAM | 1857 | 209,852 | 5.27 | 1 | 1 |
38. | O60218 | Aldo–keto reductase family 1 member B10 | AKR1B10 | 316 | 36,020 | 7.66 | 1 | 1 |
39. | O60635 | Tetraspanin-1 | TSPAN1 | 241 | 26,301 | 5.12 | 1 | 1 |
40. | O75368 | SH3 domain-binding glutamic acid-rich-like protein | SH3BGRL | 114 | 12,774 | 5.22 | 1 | 1 |
41. | P00390 | Glutathione reductase, mitochondrial | GSR | 522 | 56,257 | 8.74 | 1 | 1 |
42. | P00505 | Aspartate aminotransferase, mitochondrial | GOT2 | 430 | 47,518 | 9.14 | 1 | 1 |
43. | P01040 | Cystatin-A | CSTA | 98 | 11,006 | 5.38 | 1 | 1 |
44. | P01704 | Immunoglobulin lambda variable 2–14 | IGLV2-14 | 120 | 12,597 | 6 | 1 | 1 |
45. | P01709 | Immunoglobulin lambda variable 2–8 | IGLV2-8 | 118 | 12,382 | 5.59 | 1 | 1 |
46. | P02750 | Leucine-rich alpha-2-glycoprotein | LRG1 | 347 | 38,178 | 6.45 | 1 | 1 |
47. | P02751 | Fibronectin | FN1 | 2477 | 272,320 | 5.32 | 1 | 1 |
48. | P02774 | Vitamin D-binding protein | GC | 474 | 52,918 | 5.32 | 1 | 1 |
49. | P04114 | Apolipoprotein B-100 | APOB | 4563 | 515,605 | 6.58 | 1 | 1 |
50. | P04179 | Superoxide dismutase [Mn], mitochondrial | SOD2 | 222 | 24,750 | 8.35 | 1 | 1 |
51. | P04792 | Heat shock protein beta-1 | HSPB1 | 205 | 22,783 | 5.98 | 1 | 1 |
52. | P05155* | Plasma protease C1 inhibitor | SERPING1 | 500 | 55,154 | 6.09 | 1 | 1 |
53. | P06865 | Beta-hexosaminidase subunit alpha | HEXA | 529 | 60,703 | 5.04 | 1 | 1 |
54. | P08571 | Monocyte differentiation antigen CD14 | CD14 | 375 | 40,076 | 5.84 | 1 | 1 |
55. | P09972 | Fructose-bisphosphatealdolase C | ALDOC | 364 | 39,456 | 6.41 | 1 | 1 |
56. | P14174 | Macrophage migration inhibitory factor | MIF | 115 | 12,476 | 7.73 | 1 | 1 |
57. | P15328 | Folate receptor alpha | FOLR1 | 257 | 29,819 | 8.3 | 1 | 1 |
58. | P15814 | Immunoglobulin lambda-like polypeptide 1 | IGLL1 | 213 | 22,963 | 10.1 | 1 | 1 |
59. | P16070 | CD44 antigen | CD44 | 742 | 81,538 | 5.13 | 1 | 1 |
60. | P17213 | Bactericidal permeability-increasing protein | BPI | 487 | 53,900 | 9.41 | 1 | 1 |
61. | P20618 | Proteasome subunit beta type-1 | PSMB1 | 241 | 26,489 | 8.27 | 1 | 1 |
62. | P22352 | Glutathione peroxidase 3 | GPX3 | 226 | 25,552 | 8.26 | 1 | 1 |
63. | P28827 | Receptor-type tyrosine-protein phosphatase mu | PTPRM | 1452 | 163,682 | 6.21 | 1 | 1 |
64. | P36871 | Phosphoglucomutase-1 | PGM1 | 562 | 61,449 | 6.3 | 1 | 1 |
65. | P36952 | Serpin B5 | SERPINB5 | 375 | 42,100 | 5.72 | 1 | 1 |
66. | P37288 | Vasopressin V1a receptor | AVPR1A | 418 | 46,800 | 9.48 | 1 | 1 |
67. | P38646 | Stress-70 protein, mitochondrial | HSPA9 | 679 | 73,680 | 5.87 | 1 | 1 |
68. | P42658 | Dipeptidylaminopeptidase-like protein 6 | DPP6 | 865 | 97,588 | 5.95 | 1 | 1 |
69. | P46940 | RasGTPase-activating-like protein IQGAP1 | IQGAP1 | 1657 | 189,252 | 6.08 | 1 | 1 |
70. | P48637 | Glutathione synthetase | GSS | 474 | 52,385 | 5.67 | 1 | 1 |
71. | P51148 | Ras-related protein Rab-5C | RAB5C | 216 | 23,483 | 8.64 | 1 | 1 |
72. | P53634 | Dipeptidyl peptidase 1 | CTSC | 463 | 51,854 | 6.53 | 1 | 1 |
73. | P54802 | Alpha-N-acetylglucosaminidase | NAGLU | 743 | 82,266 | 6.2 | 1 | 1 |
74. | P60900 | Proteasome subunit alpha type-6 | PSMA6 | 246 | 27,399 | 6.35 | 1 | 1 |
75. | P78324 | Tyrosine-protein phosphatase non-receptor type substrate 1 | SIRPA | 504 | 54,967 | 6.51 | 1 | 1 |
76. | P78357 | Contactin-associated protein 1 | CNTNAP1 | 1384 | 156,267 | 6.61 | 1 | 1 |
77. | P78417 | Glutathione S-transferase omega-1 | GSTO1 | 241 | 27,566 | 6.24 | 1 | 1 |
78. | Q01082 | Spectrin beta chain, non-erythrocytic 1 | SPTBN1 | 2364 | 274,609 | 5.39 | 1 | 1 |
79. | Q05639 | Elongation factor 1-alpha 2 | EEF1A2 | 463 | 50,470 | 9.11 | 1 | 1 |
80. | Q08211 | ATP-dependent RNA helicase A | DHX9 | 1270 | 140,958 | 6.41 | 1 | 1 |
81. | Q13231 | Chitotriosidase-1 | CHIT1 | 466 | 51,681 | 6.55 | 1 | 1 |
82. | Q13490 | Baculoviral IAP repeat-containing protein 2 | BIRC2 | 618 | 69,900 | 6.27 | 1 | 1 |
83. | Q13634 | Cadherin-18 | CDH18 | 790 | 88,073 | 4.98 | 1 | 1 |
84. | Q15084 | Protein disulfide-isomerase A6 | PDIA6 | 440 | 48,121 | 4.95 | 1 | 1 |
85. | Q16651 | Prostasin | PRSS8 | 343 | 36,431 | 5.52 | 1 | 1 |
86. | Q16769 | Glutaminyl-peptide cyclotransferase | QPCT | 361 | 40,877 | 6.12 | 1 | 1 |
87. | Q5SRE7 | Phytanoyl-CoA dioxygenase domain-containing protein 1 | PHYHD1 | 291 | 32,411 | 5.88 | 1 | 1 |
88. | Q5TCS8 | Adenylate kinase 9 | AK9 | 1911 | 221,413 | 4.96 | 1 | 1 |
89. | Q6UWV7 | Protein shisa-like-2A | FAM159A | 190 | 20,306 | 4.94 | 1 | 1 |
90. | Q6ZN66 | Guanylate-binding protein 6 | GBP6 | 633 | 72,427 | 5.98 | 1 | 1 |
91. | Q86XD5 | Protein FAM131B | FAM131B | 332 | 35,769 | 4.34 | 1 | 1 |
92. | Q86YV5 | Inactive tyrosine-protein kinase PRAG1 | SGK223 | 1406 | 149,624 | 6.83 | 1 | 1 |
93. | Q8N556 | Actin filament-associated protein 1 | AFAP1 | 730 | 80,725 | 8.87 | 1 | 1 |
94. | Q8TAA3 | Proteasome subunit alpha-type 8 | PSMA8 | 256 | 28,530 | 9.07 | 1 | 1 |
95. | Q8WVC0 | RNA polymerase-associated protein LEO1 | LEO1 | 666 | 75,404 | 4.38 | 1 | 1 |
96. | Q8WWA0 | Intelectin-1 | ITLN1 | 313 | 34,962 | 5.66 | 1 | 1 |
97. | Q96G75 | E3 ubiquitin-protein transferase RMND5B | RMND5B | 393 | 44,414 | 6.15 | 1 | 1 |
98. | Q9BYZ2 | L-lactate dehydrogenase A-like 6B | LDHAL6B | 381 | 41,943 | 8.88 | 1 | 1 |
99. | Q9H0W9 | Ester hydrolase C11orf54 | C11orf54 | 315 | 35,117 | 6.23 | 1 | 1 |
100. | Q9UBR2 | Cathepsin Z | CTSZ | 303 | 33,868 | 6.7 | 1 | 1 |
101. | Q9UJ42 | Probable G-protein coupled receptor 160 | GPR160 | 338 | 39,787 | 8.84 | 1 | 1 |
